Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes. - sprookjes - yvandenbroek - TriplyDB

Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes.

Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes.

http://www.wikidata.org/entity/Q33933875

about

Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer Deciphering the molecular nature of ovarian cancer biomarker CA125 Ocular surface mucins and local inflammation--studies in genetically modified mouse lines Targeted immune therapy of ovarian cancer MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress Siglec-mediated regulation of immune cell function in disease.MUC16 mucin (CA125) attenuates TRAIL-induced apoptosis by decreasing TRAIL receptor R2 expression and increasing c-FLIP expression Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.Sialoside-based pattern recognitions discriminating infections from tissue injuries.Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing.HN125: A Novel Immunoadhesin Targeting MUC16 with Potential for Cancer Therapy The immunomodulating roles of glycoproteins in epithelial ovarian cancer.Immunity and immune suppression in human ovarian cancer.Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.Transmembrane mucins as novel therapeutic targets Mucin 16 is a functional selectin ligand on pancreatic cancer cells Tumor-Associated Glycans and Immune Surveillance The mucin MUC16 (CA125) binds to NK cells and monocytes from peripheral blood of women with healthy pregnancy and preeclampsia.Mechanisms and Targets Involved in Dissemination of Ovarian Cancer.Pathobiological implications of mucin glycans in cancer: Sweet poison and novel targets.Molecular basis of antibody binding to mucin glycopeptides in lung cancer Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon.Analysis of tumor-associated mucin glycotopes by Western transfer methods Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB.Evidence for Differential Glycosylation of Trophoblast Cell Types.C-terminus of MUC16 activates Wnt signaling pathway through its interaction with β-catenin to promote tumorigenesis and metastasis.Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer.Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion.Altered tumor-cell glycosylation promotes metastasis.The role of glycans in immune evasion: the human fetoembryonic defence system hypothesis revisited The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9.Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance.Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer.The sweet side of tumor immunotherapy.Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target.Review of the adenocarcinoma cell surface receptor for human alpha-fetoprotein; proposed identification of a widespread mucin as the tumor cell receptor.Cancer intelligence acquired (CIA): tumor glycosylation and sialylation codes dismantling antitumor defense.Understanding the Unique Attributes of MUC16 (CA125): Potential Implications in Targeted Therapy.Role of lectin microarrays in cancer diagnosis.

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Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes.

http://www.wikidata.org/entity/Q33933875

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2010 nî lūn-bûn

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2010年の論文

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Claudine Rancourt

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Gubbels A A Jennifer

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Hans-Joachim Gabius

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Sabine André

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Sachi Horibata

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P2860

Characterization of the tumor marker muc16 (ca125) expressed by murine ovarian tumor cell lines and identification of a panel of cross-reactive monoclonal antibodies

Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells

Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways

Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion

MUC16 mucin is expressed by the human ocular surface epithelia and carries the H185 carbohydrate epitope

Reactivity of a monoclonal antibody with human ovarian carcinoma

Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors

Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125

Mucins in cancer: protection and control of the cell surface

Structure and function of the cell surface (tethered) mucins

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