about
Melanoma: from melanocyte to genetic alterations and clinical optionsRequirement of Cdk4 for v-Ha-ras-Induced Breast Tumorigenesis and Activation of the v-ras-Induced Senescence Program by the R24C MutationCurrent State of Animal (Mouse) Modeling in Melanoma ResearchReconstructing skin cancers using animal modelsGenetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell numberAn essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stressARF-induced downregulation of Mip130/LIN-9 protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf.Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas.Surprising dependency for retinoblastoma protein in ras-mediated tumorigenesisThe role of microRNAs and long non-coding RNAs in the pathology, diagnosis, and management of melanomaCooperativity of Cdk4R24C and Ras in melanoma development.Genotyping of cutaneous melanoma.Progression in cutaneous malignant melanoma is associated with distinct expression profiles: a tissue microarray-based study.Oncogenes in melanoma.The INK4a/ARF locus and melanoma.Recent advances in sunlight-induced carcinogenesis using the Xiphophorus melanoma modelRapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation.Cdk4 deficiency inhibits skin tumor development but does not affect normal keratinocyte proliferation.Targeted Therapies in Melanoma: Translational Research at Its Finest.Cyclin-Dependent Kinase Inhibitors as Anticancer TherapeuticsDual suppression of the cyclin-dependent kinase inhibitors CDKN2C and CDKN1A in human melanoma.Regulation of the G1/S phase of the cell cycle and alterations in the RB pathway in human lung cancer.CDK4: A Key Player in the Cell Cycle, Development, and CancerCutaneous melanoma in genetically modified animals.p16INK4a-induced senescence is disabled by melanoma-associated mutationsp21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia.Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.Role of the G Protein-Coupled Receptor, mGlu1, in Melanoma Development.Cell cycle proteins as promising targets in cancer therapyModelling melanoma in mice.T cell immunotherapy for melanoma from bedside to bench to barn and back: how conceptual advances in experimental mouse models can be translated into clinical benefit for patients.Skin Tumors Rb(eing) Uncovered.Deletion of ADAM-9 in HGF/CDK4 mice impairs melanoma development and metastasis.The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma.Genetically engineered mouse models of melanoma.Mouse melanoma models and cell lines.p53 prevents progression of nevi to melanoma predominantly through cell cycle regulationEnhanced malignant tumorigenesis in Cdk4 transgenic mice.
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Invasive melanoma in Cdk4-targeted mice.
@ast
Invasive melanoma in Cdk4-targeted mice.
@en
type
label
Invasive melanoma in Cdk4-targeted mice.
@ast
Invasive melanoma in Cdk4-targeted mice.
@en
prefLabel
Invasive melanoma in Cdk4-targeted mice.
@ast
Invasive melanoma in Cdk4-targeted mice.
@en
P2093
P2860
P356
P1476
Invasive melanoma in Cdk4-targeted mice.
@en
P2093
Barbacid M
Malumbres M
P2860
P304
13312-13317
P356
10.1073/PNAS.241338598
P407
P577
2001-10-23T00:00:00Z