The molecular regulation of Janus kinase (JAK) activation - sprookjes - yvandenbroek - TriplyDB

The molecular regulation of Janus kinase (JAK) activation

The molecular regulation of Janus kinase (JAK) activation

http://www.wikidata.org/entity/Q33956113

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The role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancer JAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indications JAK2 activation by growth hormone and other cytokines Crystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activation Pseudokinases: update on their functions and evaluation as new drug targets.Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFκB pathways in cholangiocarcinoma cells.The biology, pathogenesis and clinical aspects of acute lymphoblastic leukemia in children with Down syndrome.SOCS3 overexpression inhibits advanced glycation end product-induced EMT in proximal tubule epithelial cells Bio-Zombie: the rise of pseudoenzymes in biology.Molecular insights into regulation of JAK2 in myeloproliferative neoplasms Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms.Local sequence assembly reveals a high-resolution profile of somatic structural variations in 97 cancer genomes.Fragment-Based Discovery of 6-Arylindazole JAK Inhibitors.PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.Methylation of SOCS3 is inversely associated with metabolic syndrome in an epigenome-wide association study of obesity Increasing JAK/STAT Signaling Function of Infant CD4+ T Cells during the First Year of Life.Signal, transduction, and the hematopoietic stem cell.Going for broke: targeting the human cancer pseudokinome.Novel therapeutic targets and predictive markers for hepatocellular carcinoma.Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck.JAK-STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects.Detection of driver and subclonal mutations in myelofibrosis: clinical impact on pharmacologic and transplant based treatment strategies.Human Pegivirus (HPgV; formerly known as GBV-C) inhibits IL-12 dependent natural killer cell function.Progress in understanding the safety and efficacy of Janus kinase inhibitors for treatment of rheumatoid arthritis.The promise of Janus kinase inhibitors in the treatment of hematological malignancies.MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3 Inhibition of cerebral ischemia/reperfusion injury-induced apoptosis: nicotiflorin and JAK2/STAT3 pathway.Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association.Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation.Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling.H3K27 Methylation Dynamics during CD4 T Cell Activation: Regulation of JAK/STAT and IL12RB2 Expression by JMJD3.Study on the mechanism of JAK2/STAT3 signaling pathway-mediated inflammatory reaction after cerebral ischemia.SOCS1: Regulator of T Cells in Autoimmunity and Cancer.The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects.Association of a genetic marker at the bovine Janus kinase 2 locus (JAK2/RsaI) with milk production traits of four cattle breeds.The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells.Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation Cytokine Receptors

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The molecular regulation of Janus kinase (JAK) activation

http://www.wikidata.org/entity/Q33956113

description

2014 nî lūn-bûn

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2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

The molecular regulation of Janus kinase (JAK) activation

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The molecular regulation of Janus kinase (JAK) activation

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The molecular regulation of Janus kinase (JAK) activation

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The molecular regulation of Janus kinase (JAK) activation

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The molecular regulation of Janus kinase (JAK) activation

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The molecular regulation of Janus kinase (JAK) activation

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Biochemical Journal

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The molecular regulation of Janus kinase (JAK) activation

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Isabelle S Lucet

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Leila N Varghese

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Nicos A Nicola

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P2860

Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

PTP1B regulates leptin signal transduction in vivo

tyk2, prototype of a novel class of non-receptor tyrosine kinase genes

Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling

A family of cytokine-inducible inhibitors of signalling

Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes

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1-13

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scholarly article

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10.1042/BJ20140712

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1

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462

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Jeffrey J Babon

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2014-08-01T00:00:00Z

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25057888

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4112375

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