The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing.
about
Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactionsHypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteinsASAP, a novel protein complex involved in RNA processing and apoptosisCDC2L5, a Cdk-like kinase with RS domain, interacts with the ASF/SF2-associated protein p32 and affects splicing in vivoDifferential effects of hyperphosphorylation on splicing factor SRp55Sorting out the complexity of SR protein functionsIdentification and characterization of a novel serine-arginine-rich splicing regulatory proteinAdaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1Regulation and substrate specificity of the SR protein kinase Clk/StyShutoff of Host Gene Expression in Influenza A Virus and Herpesviruses: Similar Mechanisms and Common ThemesThe Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular DifferentiationDefects in spliceosomal machinery: a new pathway of leukaemogenesisPhosphorylation-mediated regulation of alternative splicing in cancerClks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint.Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative SplicingEvidence for a role of Sky1p-mediated phosphorylation in 3' splice site recognition involving both Prp8 and Prp17/Slu4.Conserved SR protein kinase functions in nuclear import and its action is counteracted by arginine methylation in Saccharomyces cerevisiaeSpermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factorsCloning of human PRP4 reveals interaction with Clk1Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of ClkMass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/StyLegionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functionsCdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesisInsulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cellsAkt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCbetaII messenger ribonucleic acidMitogen-activated protein kinase phosphorylation of splicing factor 45 (SPF45) regulates SPF45 alternative splicing site utilization, proliferation, and cell adhesion.Son is essential for nuclear speckle organization and cell cycle progression.The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins.Expression of Arabidopsis SR-like splicing proteins confers salt tolerance to yeast and transgenic plants.Serological identification of adult T-cell leukaemia-associated antigens.Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing.Optimization of a weak 3' splice site counteracts the function of a bovine papillomavirus type 1 exonic splicing suppressor in vitro and in vivoNova autoregulation reveals dual functions in neuronal splicing.Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells.Regulation of SR protein localization during developmentDistinctive features of Drosophila alternative splicing factor RS domain: implication for specific phosphorylation, shuttling, and splicing activationUV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation.Regulated cellular partitioning of SR protein-specific kinases in mammalian cellsB-cell and plasma-cell splicing differences: a potential role in regulated immunoglobulin RNA processing.Exonic splicing enhancer-dependent selection of the bovine papillomavirus type 1 nucleotide 3225 3' splice site can be rescued in a cell lacking splicing factor ASF/SF2 through activation of the phosphatidylinositol 3-kinase/Akt pathway.
P2860
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P2860
The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing.
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The protein kinase Clk/Sty dir ...... sphorylation inhibit splicing.
@ast
The protein kinase Clk/Sty dir ...... sphorylation inhibit splicing.
@en
type
label
The protein kinase Clk/Sty dir ...... sphorylation inhibit splicing.
@ast
The protein kinase Clk/Sty dir ...... sphorylation inhibit splicing.
@en
prefLabel
The protein kinase Clk/Sty dir ...... sphorylation inhibit splicing.
@ast
The protein kinase Clk/Sty dir ...... sphorylation inhibit splicing.
@en
P2093
P2860
P356
P1476
The protein kinase Clk/Sty dir ...... sphorylation inhibit splicing.
@en
P2093
P2860
P304
P356
10.1128/MCB.19.10.6991
P407
P577
1999-10-01T00:00:00Z