New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsins

New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsins

Item
http://www.wikidata.org/entity/Q33982942
Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine.Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.Characterisation of hydrazides and hydrazine derivatives as novel aspartic protease inhibitors.Catestatin, an endogenous chromogranin A-derived peptide, inhibits in vitro growth of Plasmodium falciparumEvaluation of Diarylureas for Activity Against Plasmodium falciparum.Antimalarial activities and therapeutic properties of febrifugine analogs.Computational perspectives into plasmepsins structure-function relationship: implications to inhibitors design.Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors.Analysis of binding interactions of pepsin inhibitor-3 to mammalian and malarial aspartic proteases.Novel diaryl ureas with efficacy in a mouse model of malaria.Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents.Novel inhibition of porcine pepsin by a substituted piperidine. Preference for one of the enzyme conformers.Plasmepsin inhibitors: design, synthesis, inhibitory studies and crystal structure analysis.Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy.The role of Plasmodium falciparum food vacuole plasmepsins.X-ray structure of plasmepsin II complexed with a potent achiral inhibitor.
P2860

New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsins

Item
http://www.wikidata.org/entity/Q33982942
description
2001 nî lūn-bûn
@nan
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
New class of small nonpeptidyl ...... itro by inhibiting plasmepsins
@ast
New class of small nonpeptidyl ...... itro by inhibiting plasmepsins
@en
type
label
New class of small nonpeptidyl ...... itro by inhibiting plasmepsins
@ast
New class of small nonpeptidyl ...... itro by inhibiting plasmepsins
@en
prefLabel
New class of small nonpeptidyl ...... itro by inhibiting plasmepsins
@ast
New class of small nonpeptidyl ...... itro by inhibiting plasmepsins
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932
P356
P1433
P1476
New class of small nonpeptidyl ...... itro by inhibiting plasmepsins
@en
P2093
P2860
P304
P31
P356
10.1128/AAC.45.9.2577-2584.2001
P407
P433
P478
P577
P5875
P698
P921
P932