Microtubule assembly dynamics: an attractive target for anticancer drugs.
about
Griseofulvin stabilizes microtubule dynamics, activates p53 and inhibits the proliferation of MCF-7 cells synergistically with vinblastineAn antitubulin agent BCFMT inhibits proliferation of cancer cells and induces cell death by inhibiting microtubule dynamicsInduction of tumor cell death through targeting tubulin and evoking dysregulation of cell cycle regulatory proteins by multifunctional cinnamaldehydesDocking, synthesis and antiproliferative activity of N-acylhydrazone derivatives designed as combretastatin A4 analoguesLarge-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug RepurposingHigh-confidence mapping of chemical compounds and protein complexes reveals novel aspects of chemical stress response in yeast.Cladosporol A triggers apoptosis sensitivity by ROS-mediated autophagic flux in human breast cancer cells.Metagenomic profiles of free-living archaea, bacteria and small eukaryotes in coastal areas of Sichang island, ThailandSynthesis of phenstatin/isocombretastatin-chalcone conjugates as potent tubulin polymerization inhibitors and mitochondrial apoptotic inducers.Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response.Overexpression of SCLIP promotes growth and motility in glioblastoma cellsTargeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell.Leveraging a high resolution microfluidic assay reveals insights into pathogenic fungal spore germinationTargeting FtsZ for antibacterial therapy: a promising avenue.Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibition.Tubulin-interactive stilbene derivatives as anticancer agents.Novel quinolone chalcones targeting colchicine-binding pocket kill multidrug-resistant cancer cells by inhibiting tubulin activity and MRP1 function.Halichondrin B amide acts as tubulin binding agent to exhibit anti-tumor efficacy in hematologic cancersEmpirical analysis of BMD metrics in genetic toxicology part I: in vitro analyses to provide robust potency rankings and support MOA determinations.Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis.Prometaphase arrest-dependent phosphorylation of Bcl-2 and Bim reduces the association of Bcl-2 with Bak or Bim, provoking Bak activation and mitochondrial apoptosis in nocodazole-treated Jurkat T cells.Synthesis and biological evaluation of truncated α-tubulin-binding pironetin analogues lacking alkyl pendants in the side chain or the dihydropyrone ring.Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation.Peloruside A inhibits microtubule dynamics in a breast cancer cell line MCF7.Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer propertiesPhosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: a reappraisal of translation initiation during mitosis.A STRIPAK component Strip regulates neuronal morphogenesis by affecting microtubule stability.ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis.Thermoresponsive Supramolecular Chemotherapy by "V"-Shaped Armed β-Cyclodextrin Star Polymer to Overcome Drug Resistance.Regulators of Spindle Microtubules and Their Mechanisms: Living Together Matters.Exploring the binding sites and binding mechanism for hydrotrope encapsulated griseofulvin drug on γ-tubulin protein.Codelivery for Paclitaxel and Bcl-2 Conversion Gene by PHB-PDMAEMA Amphiphilic Cationic Copolymer for Effective Drug Resistant Cancer Therapy.Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of glioma cells by inactivating Wnt/β-catenin signaling.Synthesis and biological evaluation of simplified pironetin analogues with modifications in the side chain and the lactone ring.A deterministic oscillatory model of microtubule growth and shrinkage for differential actions of short chain fatty acids.Drug-Clinical Agent Molecular Hybrid: Synthesis of Diaryl(trifluoromethyl)pyrazoles as Tubulin Targeting Anticancer Agents.Chemoselective fluorination and chemoinformatic analysis of griseofulvin: Natural vs fluorinated fungal metabolitesPyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization
P2860
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P2860
Microtubule assembly dynamics: an attractive target for anticancer drugs.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Microtubule assembly dynamics: an attractive target for anticancer drugs.
@ast
Microtubule assembly dynamics: an attractive target for anticancer drugs.
@en
Microtubule assembly dynamics: an attractive target for anticancer drugs.
@nl
type
label
Microtubule assembly dynamics: an attractive target for anticancer drugs.
@ast
Microtubule assembly dynamics: an attractive target for anticancer drugs.
@en
Microtubule assembly dynamics: an attractive target for anticancer drugs.
@nl
prefLabel
Microtubule assembly dynamics: an attractive target for anticancer drugs.
@ast
Microtubule assembly dynamics: an attractive target for anticancer drugs.
@en
Microtubule assembly dynamics: an attractive target for anticancer drugs.
@nl
P2093
P2860
P356
P1433
P1476
Microtubule assembly dynamics: an attractive target for anticancer drugs.
@en
P2093
Dulal Panda
Krishnan Rathinasamy
Parminder Singh
Renu Mohan
P2860
P304
P356
10.1002/IUB.42
P577
2008-06-01T00:00:00Z