Enzyme promiscuity: a mechanistic and evolutionary perspective.
about
Evolution of minimal specificity and promiscuity in steroid hormone receptorsReconstruction of ancestral metabolic enzymes reveals molecular mechanisms underlying evolutionary innovation through gene duplicationHow drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusionCofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymesIdentification of human fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) as a novel mitochondrial acylpyruvaseA large-scale evaluation of computational protein function predictionHigh-resolution analysis of Zn(2+) coordination in the alkaline phosphatase superfamily by EXAFS and x-ray crystallographyEngineering of TEV protease variants by yeast ER sequestration screening (YESS) of combinatorial librariesCatalytic Promiscuity of the Radical S-adenosyl-L-methionine Enzyme NosLHow special is the biochemical function of native proteins?Radical-Mediated Enzymatic PolymerizationsThe Impact of Non-Enzymatic Reactions and Enzyme Promiscuity on Cellular Metabolism during (Oxidative) Stress ConditionsA review of metabolic and enzymatic engineering strategies for designing and optimizing performance of microbial cell factoriesApplications of targeted proteomics in systems biology and translational medicineRevealing the properties of plant defensins through dynamicsComputer aided enzyme design and catalytic conceptsThe role of robustness in phenotypic adaptation and innovationImplications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical functionAre there errors in glycogen biosynthesis and is laforin a repair enzyme?Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics.Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed EvolutionStructure of a Peptidoglycan Amidase Effector Targeted to Gram-Negative Bacteria by the Type VI Secretion SystemStructural and Enzymatic characterization of the lactonase SisLac from Sulfolobus islandicusThe X-ray crystallographic structure and specificity profile of HAD superfamily phosphohydrolase BT1666: Comparison of paralogous functions inB. thetaiotaomicronDetermination of the Structure of the Catabolic N-Succinylornithine Transaminase (AstC) from Escherichia coliComputational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysisA Single Mutation in a Regulatory Protein Produces Evolvable Allosterically Regulated Catalyst of Nonnatural ReactionMolecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase TemplateStructure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and SerotoninDifferential active site loop conformations mediate promiscuous activities in the lactonase SsoPoxThe molecular basis of phosphate discrimination in arsenate-rich environmentsSubstrate Deconstruction and the Nonadditivity of Enzyme RecognitionIP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase familyStructure and Catalysis in the Escherichia coli Hotdog-fold Thioesterase Paralogs YdiI and YbdBSwitching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263TrpThe crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activitiesA novel esterase subfamily with α/β-hydrolase fold suggested by structures of two bacterial enzymes homologous to L-homoserine O-acetyl transferasesExploitation of latent allostery enables the evolution of new modes of MAP kinase regulationSimilarities and differences in the biochemical and enzymological properties of the four isomaltases from Saccharomyces cerevisiae.The Generation and Exploitation of Protein Mutability Landscapes for Enzyme Engineering
P2860
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P2860
Enzyme promiscuity: a mechanistic and evolutionary perspective.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Enzyme promiscuity: a mechanistic and evolutionary perspective.
@ast
Enzyme promiscuity: a mechanistic and evolutionary perspective.
@en
Enzyme promiscuity: a mechanistic and evolutionary perspective.
@nl
type
label
Enzyme promiscuity: a mechanistic and evolutionary perspective.
@ast
Enzyme promiscuity: a mechanistic and evolutionary perspective.
@en
Enzyme promiscuity: a mechanistic and evolutionary perspective.
@nl
prefLabel
Enzyme promiscuity: a mechanistic and evolutionary perspective.
@ast
Enzyme promiscuity: a mechanistic and evolutionary perspective.
@en
Enzyme promiscuity: a mechanistic and evolutionary perspective.
@nl
P1476
Enzyme promiscuity: a mechanistic and evolutionary perspective.
@en
P2093
Dan S Tawfik
Olga Khersonsky
P304
P356
10.1146/ANNUREV-BIOCHEM-030409-143718
P577
2010-01-01T00:00:00Z