Nicotinic partial agonists varenicline and sazetidine-A have differential effects on affective behavior.
about
Nicotine receptors and depression: revisiting and revising the cholinergic hypothesisEnantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selective α4β2-nAChR Ligands.Low dose nicotine and antagonism of β2 subunit containing nicotinic acetylcholine receptors have similar effects on affective behavior in miceNicotinic ligands as multifunctional agents for the treatment of neuropsychiatric disordersDissociation of tolerance and nicotine withdrawal-associated deficits in contextual fear.Discovery of potent positive allosteric modulators of the α3β2 nicotinic acetylcholine receptor by a chemical space walk in ChEMBL.The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile.Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors.Parallel anxiolytic-like effects and upregulation of neuronal nicotinic acetylcholine receptors following chronic nicotine and varenicline.Translational Research on Nicotine Dependence.Contributions of β2 subunit-containing nAChRs to chronic nicotine-induced alterations in cognitive flexibility in mice.Discovery of isoxazole analogues of sazetidine-A as selective α4β2-nicotinic acetylcholine receptor partial agonists for the treatment of depressionAnxiolytic-like and anxiogenic-like effects of nicotine are regulated via diverse action at β2*nicotinic acetylcholine receptorsDissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380.Chemistry and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profileNicotinic receptor contributions to smoking: insights from human studies and animal modelsVarenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivoThe antinociceptive effects of nicotinic partial agonists varenicline and sazetidine-A in murine acute and tonic pain modelsEffects of the BDNF Val66Met Polymorphism on Anxiety-Like Behavior Following Nicotine Withdrawal in Mice.Chronic treatment with varenicline changes expression of four nAChR binding sites in mice.Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain.A new radioligand binding assay to measure the concentration of drugs in rodent brain ex vivo.Anxiolytic- and antidepressant-like effects of the methadone metabolite 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP).Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.Divergent functional effects of sazetidine-a and varenicline during nicotine withdrawal.Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in ratsA positive relationship between harm avoidance and brain nicotinic acetylcholine receptor availability.Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence.Activation of α4β2*/α6β2* nicotinic receptors alleviates anxiety during nicotine withdrawal without upregulating nicotinic receptors.Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brainCholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: an overview of preclinical and clinical findings.Allosteric modulators of α4β2 nicotinic acetylcholine receptors: a new direction for antidepressant drug discovery.Nicotine Addiction and Psychiatric Disorders.The (α4)3(β2)2 Stoichiometry of the Nicotinic Acetylcholine Receptor Predominates in the Rat Motor Cortex.Substance use modulates stress reactivity: Behavioral and physiological outcomes.Targeting the Cholinergic System to Develop a Novel Therapy for Huntington's DiseaseAcute activation, desensitization and smoldering activation of human acetylcholine receptors.Distinct Roles of CREB Within the Ventral and Dorsal Hippocampus in Mediating Nicotine Withdrawal Phenotypes.TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors.Selective deletion of a cell cycle checkpoint kinase (ATR) reduces neurogenesis and alters responses in rodent models of behavioral affect.
P2860
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P2860
Nicotinic partial agonists varenicline and sazetidine-A have differential effects on affective behavior.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Nicotinic partial agonists var ...... effects on affective behavior.
@ast
Nicotinic partial agonists var ...... effects on affective behavior.
@en
Nicotinic partial agonists var ...... effects on affective behavior.
@nl
type
label
Nicotinic partial agonists var ...... effects on affective behavior.
@ast
Nicotinic partial agonists var ...... effects on affective behavior.
@en
Nicotinic partial agonists var ...... effects on affective behavior.
@nl
prefLabel
Nicotinic partial agonists var ...... effects on affective behavior.
@ast
Nicotinic partial agonists var ...... effects on affective behavior.
@en
Nicotinic partial agonists var ...... effects on affective behavior.
@nl
P2860
P356
P1476
Nicotinic partial agonists var ...... effects on affective behavior
@en
P2093
Julie A Blendy
Laura M Castellano
P2860
P304
P356
10.1124/JPET.110.166280
P407
P577
2010-04-30T00:00:00Z