HDAC6 inhibition restores ciliary expression and decreases tumor growth - sprookjes - yvandenbroek - TriplyDB

HDAC6 inhibition restores ciliary expression and decreases tumor growth

HDAC6 inhibition restores ciliary expression and decreases tumor growth

http://www.wikidata.org/entity/Q34035361

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Cilia in autophagy and cancer Molecular views of Arf-like small GTPases in cilia and ciliopathies RhoA Ambivalently Controls Prominent Myofibroblast Characteritics by Involving Distinct Signaling Routes HDAC6 is overexpressed in cystic cholangiocytes and its inhibition reduces cystogenesis FAM65B controls the proliferation of transformed and primary T cells.Proteasome inhibition reverses hedgehog inhibitor and taxane resistance in ovarian cancer.Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide.Loss of primary cilia occurs early in breast cancer development.Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma.Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly.A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma Functional interplay between cylindromatosis and histone deacetylase 6 in ciliary homeostasis revealed by phenotypic analysis of double knockout mice.Inhibition of Hedgehog signaling in the gastrointestinal tract: targeting the cancer microenvironment.The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease.HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma.HDAC6-mediated EGFR stabilization and activation restrict cell response to sorafenib in non-small cell lung cancer cells.Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA).The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome.Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma.The cholangiocyte primary cilium in health and disease.Pathobiology of biliary epithelia.TGR5 in the Cholangiociliopathies.The Fungal Metabolite Brefeldin A Inhibits Dvl2-Plk1-Dependent Primary Cilium Disassembly Primary cilia are lost in preinvasive and invasive prostate cancer.A Glasgow Tipple-transjugular intrahepatic portosystemic shunt insertion prior to Whipple resection Chlamydomonas FAP265 is a tubulin polymerization promoting protein, essential for flagellar reassembly and hatching of daughter cells from the sporangium.Vorinostat-eluting poly(DL-lactide-co-glycolide) nanofiber-coated stent for inhibition of cholangiocarcinoma cells.Critical role of the HDAC6-cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect.Maintaining centrosomes and cilia.Olfactory loss and dysfunction in ciliopathies: Molecular mechanisms and potential therapies.Primary cilia: Cell and molecular mechanosensors directing whole tissue function.LPA signaling is regulated through the primary cilium: a novel target in glioblastoma.Primary Cilia in Brain Development and Diseases.A synthetic combinatorial approach to disabling deviant Hedgehog signaling.SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma.The combination of an HDAC6 inhibitor and a somatostatin receptor agonist synergistically reduces hepato-renal cystogenesis in an animal model of polycystic liver disease.MiR-433 and miR-22 dysregulations induce HDAC6 overexpression and ciliary loss in cholangiocarcinoma.Therapie des metastasierten Cholangiokarzinoms Oncometabolite induced primary cilia loss in pheochromocytoma

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P2860

HDAC6 inhibition restores ciliary expression and decreases tumor growth

http://www.wikidata.org/entity/Q34035361

description

2013 nî lūn-bûn

@nan

2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հունվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

HDAC6 inhibition restores ciliary expression and decreases tumor growth

@ast

HDAC6 inhibition restores ciliary expression and decreases tumor growth

@en

HDAC6 inhibition restores ciliary expression and decreases tumor growth

@nl

type

label

HDAC6 inhibition restores ciliary expression and decreases tumor growth

@ast

HDAC6 inhibition restores ciliary expression and decreases tumor growth

@en

HDAC6 inhibition restores ciliary expression and decreases tumor growth

@nl

prefLabel

HDAC6 inhibition restores ciliary expression and decreases tumor growth

@ast

HDAC6 inhibition restores ciliary expression and decreases tumor growth

@en

HDAC6 inhibition restores ciliary expression and decreases tumor growth

@nl

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0008-5472.CAN-12-2938

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Cancer Research

P1476

HDAC6 inhibition restores ciliary expression and decreases tumor growth

@en

P2093

Bing Q Huang

http://www.w3.org/2001/XMLSchema#string

Brynn N Radtke

http://www.w3.org/2001/XMLSchema#string

Gabriella B Gajdos

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Nicholas F LaRusso

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Pamela S Bogert

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Sergio A Gradilone

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P2860

The role of HDAC6 in cancer

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

HEF1-dependent Aurora A activation induces disassembly of the primary cilium

Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.

A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p

VHL inactivation induces HEF1 and Aurora kinase A

Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors

Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling

Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella

Up-regulation of microRNA 506 leads to decreased Cl-/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis.

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2259-2270

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scholarly article

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10.1158/0008-5472.CAN-12-2938

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7

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73

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2013-01-31T00:00:00Z

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23370327

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3768151

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