Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. - sprookjes - yvandenbroek - TriplyDB

Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects.

Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects.

http://www.wikidata.org/entity/Q34074250

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Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputs The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6 Furin at the cutting edge: from protein traffic to embryogenesis and disease Engineering the gut for insulin replacement to treat diabetes 60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides Obesity genetics in mouse and human: back and forth, and back again The association of common variants in PCSK1 with obesity: a HuGE review and meta-analysis Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter Functional consequences of a novel variant of PCSK1 Metabolic and Behavioural Phenotypes in Nestin-Cre Mice Are Caused by Hypothalamic Expression of Human Growth Hormone Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addict Intracellular trafficking of thyroid peroxidase to the cell surface Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cells Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function.Role of PCSK5 expression in mouse ovarian follicle development: identification of the inhibin α- and β-subunits as candidate substrates.Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics.Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic α-cells in mouse models of ß-cell regeneration.Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.Modulation of prohormone convertase 1/3 properties using site-directed mutagenesis.What lies ahead for the proprotein convertases?Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse The dwarf phenotype in GH240B mice, haploinsufficient for the autism candidate gene Neurobeachin, is caused by ectopic expression of recombinant human growth hormone.Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing.Impaired enteroendocrine development in intestinal-specific Islet1 mouse mutants causes impaired glucose homeostasis.The effects of fluorouracil, epirubicin, and cyclophosphamide (FEC60) on the intestinal barrier function and gut peptides in breast cancer patients: an observational study.MAFA controls genes implicated in insulin biosynthesis and secretion Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency.Proprotein convertase 1/3 (PC1/3) in the rat alveolar macrophage cell line NR8383: localization, trafficking and effects on cytokine secretion.Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation The role of incretins in glucose homeostasis and diabetes treatment.Adventures with insulin in the islets of Langerhans Hypothalamic proopiomelanocortin processing and the regulation of energy balance Dysgenesis of enteroendocrine cells in Aristaless-Related Homeobox polyalanine expansion mutations.

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P2860

Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects.

http://www.wikidata.org/entity/Q34074250

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2002 nî lūn-bûn

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2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2002年の論文

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Disruption of PC1/3 expression ...... ne peptide processing defects.

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Disruption of PC1/3 expression ...... ne peptide processing defects.

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Disruption of PC1/3 expression ...... ne peptide processing defects.

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Disruption of PC1/3 expression ...... ne peptide processing defects.

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Disruption of PC1/3 expression ...... ne peptide processing defects.

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Disruption of PC1/3 expression ...... ne peptide processing defects.

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Disruption of PC1/3 expression ...... ne peptide processing defects.

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Disruption of PC1/3 expression ...... ne peptide processing defects.

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Disruption of PC1/3 expression ...... ne peptide processing defects.

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Proceedings of the National Academy of Sciences of the United States of America

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Disruption of PC1/3 expression ...... ne peptide processing defects.

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An Zhou

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Arunangsu Dey

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Christina Norrbom

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Chunling Zhang

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Donald F Steiner

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Iris Lindberg

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Virginie Laurent

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Xiaorong Zhu

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P2860

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments

Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans.

The mutant growth hormone-releasing hormone (GHRH) receptor of the little mouse does not bind GHRH

Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals

Brief report: impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function

Impaired fertility in mice deficient for the testicular germ-cell protease PC4

Stimulation of growth in the little mouse

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10293-10298

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10.1073/PNAS.162352599

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16

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99

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Jens Juul Holst

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11237737

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