Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B.
about
Solution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthaseBioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coliSynthetic biology approaches in drug discovery and pharmaceutical biotechnology.Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism.Roles of type II thioesterases and their application for secondary metabolite yield improvement.The garden of antimicrobial delightsBiosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host.Engineered polyketide biosynthesis and biocatalysis in Escherichia coli.Improved precursor-directed biosynthesis in E. coli via directed evolution.Rational improvement of simvastatin synthase solubility in Escherichia coli leads to higher whole-cell biocatalytic activity.The enzymology of combinatorial biosynthesis.An erythromycin process improvement using the diethyl methylmalonate-responsive (Dmr) phenotype of the Saccharopolyspora erythraea mutB strainEngineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli.Combinatorial biosynthesis of reduced polyketides.The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites.Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in Streptomyces sp. strain FR-008.Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.Opportunities for synthetic biology in antibiotics: expanding glycopeptide chemical diversity.Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters.The role of transcription in heterologous expression of polyketides in bacterial hosts.Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in Escherichia coli.Production of the polyketide 6-deoxyerythronolide B in the heterologous host Bacillus subtilis.Efficient synthesis of simvastatin by use of whole-cell biocatalysis.Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1.A non-canonical peptide synthetase adenylates 3-methyl-2-oxovaleric acid for auriculamide biosynthesis.Three thioesterases are involved in the biosynthesis of phosphinothricin tripeptide in Streptomyces viridochromogenes Tü494.Characterization of TioQ, a type II thioesterase from the thiocoraline biosynthetic cluster.Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin.Generate a bioactive natural product library by mining bacterial cytochrome P450 patterns.Construction of polyketide overproducing Escherichia coli strains via synthetic antisense RNAs based on in silico fluxome analysis and comparative transcriptome analysis.Improving heterologous polyketide production in Escherichia coli by transporter engineering.Recycling of over-activated acyls by a Type II Thioesterase during Calcimycin biosynthesis in Streptomyces chartreusis NRRL 3882.
P2860
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P2860
Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Process and metabolic strategi ...... erived 6-deoxyerythronolide B.
@ast
Process and metabolic strategi ...... erived 6-deoxyerythronolide B.
@en
Process and metabolic strategi ...... erived 6-deoxyerythronolide B.
@nl
type
label
Process and metabolic strategi ...... erived 6-deoxyerythronolide B.
@ast
Process and metabolic strategi ...... erived 6-deoxyerythronolide B.
@en
Process and metabolic strategi ...... erived 6-deoxyerythronolide B.
@nl
prefLabel
Process and metabolic strategi ...... erived 6-deoxyerythronolide B.
@ast
Process and metabolic strategi ...... erived 6-deoxyerythronolide B.
@en
Process and metabolic strategi ...... erived 6-deoxyerythronolide B.
@nl
P2093
P2860
P1476
Process and metabolic strategi ...... erived 6-deoxyerythronolide B.
@en
P2093
Blaine Pfeifer
Chaitan Khosla
Peter Licari
P2860
P304
P356
10.1128/AEM.68.7.3287-3292.2002
P407
P577
2002-07-01T00:00:00Z