Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture.
about
Beyond directed evolution--semi-rational protein engineering and designSolvents and sustainable chemistryMicrobial enzymes: tools for biotechnological processesCrystal structures of the Chromobacterium violaceumω-transaminase reveal major structural rearrangements upon binding of coenzyme PLPStructural studies ofPseudomonasandChromobacteriumω-aminotransferases provide insights into their differing substrate specificityCrystal Structure of an (R)-Selective ω-Transaminase from Aspergillus terreusThe substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase fromNectria haematococcaBioretrosynthetic construction of a didanosine biosynthetic pathwayRedesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalinThe role of distant mutations and allosteric regulation on LovD active site dynamicsCrystallographic characterization of the (R)-selective amine transaminase from Aspergillus fumigatusL-allo-threonine aldolase with an H128Y/S292R mutation from Aeromonas jandaei DK-39 reveals the structural basis of changes in substrate stereoselectivityAdvances in the directed evolution of proteins.Structural and biochemical characterization of the dual substrate recognition of the (R)-selective amine transaminase from Aspergillus fumigatusDirected divergent evolution of a thermostable D-tagatose epimerase towards improved activity for two hexose substratesCatalytic Promiscuity of Transaminases: Preparation of Enantioenriched β-Fluoroamines by Formal Tandem Hydrodefluorination/DeaminationDirected evolution: tailoring biocatalysts for industrial applicationsThermostabilization of an esterase by alignment-guided focussed directed evolutionStrategies for discovery and improvement of enzyme function: state of the art and opportunitiesNitrilases in nitrile biocatalysis: recent progress and forthcoming researchBiocatalyst development by directed evolutionA roadmap for biocatalysis - functional and spatial orchestration of enzyme cascadesConversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascadesCombining a Clostridial enzyme exhibiting unusual active site plasticity with a remarkably facile sigmatropic rearrangement: rapid, stereocontrolled entry into densely functionalized fluorinated phosphonates for chemical biologyThe evolution of drug design at Merck Research Laboratories.NewProt - a protein engineering portal.Protein engineering: navigating between chance and reason.Use of hydrostatic pressure for modulation of protein chemical modification and enzymatic selectivity.How the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: the Serine-Histidine-Aspartate Catalytic Triad of α/β-Hydrolase Fold Enzymes.Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenaseMetabolic engineering for the production of natural products.A general strategy for the evolution of bond-forming enzymes using yeast displayCombinatorial reshaping of the Candida antarctica lipase A substrate pocket for enantioselectivity using an extremely condensed library.Synthetic biology: regulating industry uses of new biotechnologies.MuteinDB: the mutein database linking substrates, products and enzymatic reactions directly with genetic variants of enzymes.An automated flow for directed evolution based on detection of promiscuous scaffolds using spatial and electrostatic properties of catalytic residues.Catalytic Enantioselective Allylic Amination of Olefins for the Synthesis of ent-Sitagliptin.Directed evolution of RebH for site-selective halogenation of large biologically active molecules.Directed evolution of an ultrastable carbonic anhydrase for highly efficient carbon capture from flue gas.Enzymatic functionalization of carbon-hydrogen bonds.
P2860
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P2860
Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.
@ast
Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.
@en
Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.
@nl
type
label
Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.
@ast
Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.
@en
Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.
@nl
prefLabel
Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.
@ast
Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.
@en
Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.
@nl
P2093
P2860
P356
P1433
P1476
Biocatalytic asymmetric synthe ...... ed to sitagliptin manufacture.
@en
P2093
Anke Krebber
Christopher K Savile
Emily C Mundorff
Fred J Fleitz
Gjalt W Huisman
Gregory J Hughes
Jacob M Janey
Jeffrey C Colbeck
Jeffrey C Moore
Jos Brands
P2860
P304
P356
10.1126/SCIENCE.1188934
P407
P577
2010-06-17T00:00:00Z