Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis
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The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretionMaternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic β-cells and disrupts glucose homeostasis.Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity.Perinatal exposure of mice to the pesticide DDT impairs energy expenditure and metabolism in adult female offspring.The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure.Minireview: cracking the metabolic code for thyroid hormone signalingResponsiveness to thyroid hormone and to ambient temperature underlies differences between brown adipose tissue and skeletal muscle thermogenesis in a mouse model of diet-induced obesity.Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis.Thyroid hormone signaling in energy homeostasis and energy metabolism.Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in miceThyroid hormone deiodinases and cancerThyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes.Coupling between Nutrient Availability and Thyroid Hormone ActivationUncoupling Proteins and the Molecular Mechanisms of Thyroid Thermogenesis.Coordinated regulation of hepatic and adipose tissue transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa speciesInactivation of the adrenergic receptor β2 disrupts glucose homeostasis in mice.The role of thyroid hormone and brown adipose tissue in energy homoeostasisBrown adipose tissue growth and development.Thyroid hormone replacement therapy: three 'simple' questions, complex answers.The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex.American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models.Sprouty1 induces a senescence-associated secretory phenotype by regulating NFκB activity: implications for tumorigenesis.Tissue-specific inactivation of type 2 deiodinase reveals multilevel control of fatty acid oxidation by thyroid hormone in the mouse.Hedgehog-mediated regulation of thyroid hormone action through iodothyronine deiodinases.Type 2 deiodinase at the crossroads of thyroid hormone actionAdipose tissue development during early life: novel insights into energy balance from small and large mammals.Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signalingMolecular pathways linking non-shivering thermogenesis and obesity: focusing on brown adipose tissue development.Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain.Pharmacological Activation of Thyroid Hormone Receptors Elicits a Functional Conversion of White to Brown Fat.Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice.Vertical sleeve gastrectomy activates GPBAR-1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in miceSleep deprivation alters thyroid hormone economy in rats.Cracking the code for thyroid hormone signaling.Thyroid hormone activation by type 2 deiodinase mediates exercise-induced peroxisome proliferator-activated receptor-γ coactivator-1α expression in skeletal muscle.Deletion of the Thyroid Hormone-Activating Type 2 Deiodinase Rescues Cone Photoreceptor Degeneration but Not Deafness in Mice Lacking Type 3 Deiodinase.Developmental exposure to bisphenol A leads to cardiometabolic dysfunction in adult mouse offspring.Brown adipose tissue: a new human organ?
P2860
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P2860
Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Absence of thyroid hormone act ...... fect in adaptive thermogenesis
@ast
Absence of thyroid hormone act ...... fect in adaptive thermogenesis
@en
Absence of thyroid hormone act ...... fect in adaptive thermogenesis
@nl
type
label
Absence of thyroid hormone act ...... fect in adaptive thermogenesis
@ast
Absence of thyroid hormone act ...... fect in adaptive thermogenesis
@en
Absence of thyroid hormone act ...... fect in adaptive thermogenesis
@nl
prefLabel
Absence of thyroid hormone act ...... fect in adaptive thermogenesis
@ast
Absence of thyroid hormone act ...... fect in adaptive thermogenesis
@en
Absence of thyroid hormone act ...... fect in adaptive thermogenesis
@nl
P2093
P2860
P356
P1433
P1476
Absence of thyroid hormone act ...... fect in adaptive thermogenesis
@en
P2093
Gordana Simovic
Jessica A Hall
Marcelo A Christoffolete
Mary Elizabeth Patti
Mayrin Correa-Medina
Scott Ribich
P2860
P304
P356
10.1210/EN.2010-0511
P407
P577
2010-07-21T00:00:00Z