Oxetanes as versatile elements in drug discovery and synthesis.
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Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in VivoExploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinAn expeditious route to eight-membered heterocycles by nickel-catalyzed cycloaddition: low-temperature C(sp)2-C(sp)3 bond cleavageSynthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.2-(Aryl-sulfonyl)oxetanes as designer 3-dimensional fragments for fragment screening: synthesis and strategies for functionalisation.Structurally Divergent Lithium Catalyzed Friedel-Crafts Reactions on Oxetan-3-ols: Synthesis of 3,3-Diaryloxetanes and 2,3-DihydrobenzofuransRhodium(i)-catalyzed stereoselective [4+2] cycloaddition of oxetanols with alkynes through C(sp3)-C(sp3) bond cleavage.Catalytic migratory oxidative coupling of nitrones through an outer-sphere C(sp3)-H activation process.Asymmetric synthesis of 2-substituted oxetan-3-ones via metalated SAMP/RAMP hydrazones.Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group.A non-diazo approach to α-oxo gold carbenes via gold-catalyzed alkyne oxidation.Modern advances in heterocyclic chemistry in drug discovery.Catalytic asymmetric nucleophilic openings of 3-substituted oxetanes.Square sugars: challenges and synthetic strategies.Irreversible endo-selective diels-alder reactions of substituted alkoxyfurans: a general synthesis of endo-cantharimides.Species differences in metabolism of EPZ015666, an oxetane-containing protein arginine methyltransferase-5 (PRMT5) inhibitor.Development of Enantiospecific Coupling of Secondary and Tertiary Boronic Esters with Aromatic Compounds.Evaluation of tert-butyl isosteres: case studies of physicochemical and pharmacokinetic properties, efficacies, and activities.Synthesis of di-, tri-, and tetrasubstituted oxetanes by rhodium-catalyzed O-H insertion and C-C bond-forming cyclizationPhotocycloadditions and photorearrangements.Site-Selective Modification of Proteins with Oxetanes.Ni(NHC)]-catalyzed cycloaddition of diynes and tropone: apparent enone cycloaddition involving an 8π insertion.An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility.Rapid assembly of functionalised spirocyclic indolines by palladium-catalysed dearomatising diallylation of indoles with allyl acetate.Direct α-arylation of ethers through the combination of photoredox-mediated C-H functionalization and the Minisci reaction.Catalytic enantioselective intermolecular desymmetrization of 3-substituted oxetanes.Discovery of a Novel Microsomal Epoxide Hydrolase-Catalyzed Hydration of a Spiro Oxetane.Putting the available chemical space to the fingertips of our scientists.A Direct Synthesis of Highly Substituted π-Rich Aromatic Heterocycles from Oxetanes.Complex bioactive alkaloid-type polycycles through efficient catalytic asymmetric multicomponent aza-Diels-Alder reaction of indoles with oxetane as directing group.Divergent mechanistic routes for the formation of gem-dimethyl groups in the biosynthesis of complex polyketides.Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium.Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo.Advancing the drug discovery and development process.Trifluoromethyl Oxetanes: Synthesis and Evaluation as a tert-Butyl Isostere.Iron(III)-Catalyzed Ring-Closing Carbonyl-Olefin Metathesis.Lithium-Catalyzed Thiol Alkylation with Tertiary and Secondary Alcohols: Synthesis of 3-Sulfanyl-Oxetanes as Bioisosteres.C-H Insertion as a Key Step to Spiro-Oxetanes, Scaffolds for Drug Discovery.Stereoselective synthesis of 2,3,4-highly substituted oxetanes by intramolecular C-C bond forming Michael addition.A Divergent Approach to the Marine Diterpenoids (+)-Dictyoxetane and (+)-Dolabellane V.
P2860
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P2860
Oxetanes as versatile elements in drug discovery and synthesis.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Oxetanes as versatile elements in drug discovery and synthesis.
@ast
Oxetanes as versatile elements in drug discovery and synthesis.
@en
Oxetanes as versatile elements in drug discovery and synthesis.
@nl
type
label
Oxetanes as versatile elements in drug discovery and synthesis.
@ast
Oxetanes as versatile elements in drug discovery and synthesis.
@en
Oxetanes as versatile elements in drug discovery and synthesis.
@nl
prefLabel
Oxetanes as versatile elements in drug discovery and synthesis.
@ast
Oxetanes as versatile elements in drug discovery and synthesis.
@en
Oxetanes as versatile elements in drug discovery and synthesis.
@nl
P2093
P356
P1476
Oxetanes as versatile elements in drug discovery and synthesis.
@en
P2093
Georg Wuitschik
Johannes A Burkhard
Klaus Müller
Mark Rogers-Evans
P304
P356
10.1002/ANIE.200907155
P407
P577
2010-11-01T00:00:00Z