about
β3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouseIntegrins and integrin-associated proteins in the cardiac myocyte.Proline-rich tyrosine kinase 2 (Pyk2) regulates IGF-I-induced cell motility and invasion of urothelial carcinoma cells.G(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets.Germ cell transport across the seminiferous epithelium during spermatogenesis.Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporterAdaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease.Free edges in epithelia as cues for motility.Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insightsTyrosine 402 phosphorylation of Pyk2 is involved in ionomycin-induced neurotransmitter releaseExtracellular ATP stimulates epithelial cell motility through Pyk2-mediated activation of the EGF receptorFenretinide Perturbs Focal Adhesion Kinase in Premalignant and Malignant Human Oral Keratinocytes. Fenretinide's Chemopreventive Mechanisms Include ECM Interactions.Fatty acid binding protein 5 promotes metastatic potential of triple negative breast cancer cells through enhancing epidermal growth factor receptor stability.Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injuryPYK-2 is tyrosine phosphorylated after activation of pituitary adenylate cyclase activating polypeptide receptors in lung cancer cells.PYK2 integrates growth factor and cytokine receptors signaling and potentiates breast cancer invasion via a positive feedback loop.An in silico high-throughput screen identifies potential selective inhibitors for the non-receptor tyrosine kinase Pyk2.Sphingosine 1-Phosphate-Induced ICAM-1 Expression via NADPH Oxidase/ROS-Dependent NF-κB Cascade on Human Pulmonary Alveolar Epithelial CellsDistinct role of Pyk2 in mediating thromboxane generation downstream of both G12/13 and integrin αIIbβ3 in plateletsTGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer.CCL18 from ascites promotes ovarian cancer cell migration through proline-rich tyrosine kinase 2 signalingTherapeutic potential and limitations of new FAK inhibitors in the treatment of cancer.Focal adhesion kinase inhibitors in the treatment of metastatic cancer: a patent review.Meaningful prevention of breast cancer metastasis: candidate therapeutics, preclinical validation, and clinical trial concerns.A role for the Ca(2+)-dependent tyrosine kinase Pyk2 in tonic depolarization-induced vascular smooth muscle contraction.Integrins and integrin-related proteins in cardiac fibrosis.PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition.A novel calcium-dependent mechanism of acquired resistance to IGF-1 receptor inhibition in prostate cancer cells.A role for the tyrosine kinase Pyk2 in depolarization-induced contraction of vascular smooth muscle.Pyk2 inhibition promotes contractile differentiation in arterial smooth muscle.Arachidonic Acid Induces ARE/Nrf2-Dependent Heme Oxygenase-1 Transcription in Rat Brain Astrocytes.Up-regulation of PYK2/PKCα-dependent haem oxygenase-1 by CO-releasing molecule-2 attenuates TNF-α-induced lung inflammation.Thrombin Enhanced Matrix Metalloproteinase-9 Expression and Migration of SK-N-SH Cells via PAR-1, c-Src, PYK2, EGFR, Erk1/2 and AP-1.Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration.A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors.Proline-Rich Protein Tyrosine Kinase 2 in Inflammation and Cancer.High expression of proline-rich tyrosine kinase 2 is associated with poor survival of hepatocellular carcinoma via regulating phosphatidylinositol 3-kinase/AKT pathway.Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Targeting Pyk2 for therapeutic intervention
@ast
Targeting Pyk2 for therapeutic intervention
@en
Targeting Pyk2 for therapeutic intervention
@nl
type
label
Targeting Pyk2 for therapeutic intervention
@ast
Targeting Pyk2 for therapeutic intervention
@en
Targeting Pyk2 for therapeutic intervention
@nl
prefLabel
Targeting Pyk2 for therapeutic intervention
@ast
Targeting Pyk2 for therapeutic intervention
@en
Targeting Pyk2 for therapeutic intervention
@nl
P2860
P1476
Targeting Pyk2 for therapeutic intervention
@en
P2093
Christopher A Lipinski
Joseph C Loftus
P2860
P304
P356
10.1517/14728220903473194
P407
P577
2010-01-01T00:00:00Z