Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis. - sprookjes - yvandenbroek - TriplyDB

Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.

Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.

http://www.wikidata.org/entity/Q34162337

about

AID targeting: old mysteries and new challenges Active demethylation in mouse zygotes involves cytosine deamination and base excision repair A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation.Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.Topoisomerase I deficiency causes RNA polymerase II accumulation and increases AID abundance in immunoglobulin variable genes A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes Identification of core DNA elements that target somatic hypermutation.The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation.Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID Competitive superhelical transitions involving cruciform extrusion Regulating infidelity: RNA-mediated recruitment of AID to DNA during class switch recombination Supercoiling in DNA and chromatin.Mutation-promoting molecular networks of uncontrolled inflammation.Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA.Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing.R Loops in the Regulation of Antibody Gene Diversification.Transcribing malignancy: transcription-associated genomic instability in cancer.Genetic instability associated with loop or stem-loop structures within transcription units can be independent of nucleotide excision repair.RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination.

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P2860

Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.

http://www.wikidata.org/entity/Q34162337

description

2012 nî lūn-bûn

@nan

2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2012年の論文

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2012年論文

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2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

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name

Negative supercoiling creates ...... for AID-mediated mutagenesis.

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Negative supercoiling creates ...... for AID-mediated mutagenesis.

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Negative supercoiling creates ...... for AID-mediated mutagenesis.

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type

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Negative supercoiling creates ...... for AID-mediated mutagenesis.

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Negative supercoiling creates ...... for AID-mediated mutagenesis.

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Negative supercoiling creates ...... for AID-mediated mutagenesis.

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Negative supercoiling creates ...... for AID-mediated mutagenesis.

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Negative supercoiling creates ...... for AID-mediated mutagenesis.

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Negative supercoiling creates ...... for AID-mediated mutagenesis.

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JOURNAL.PGEN.1002518

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Negative supercoiling creates ...... for AID-mediated mutagenesis.

@en

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Ahmad Zaheen

http://www.w3.org/2001/XMLSchema#string

Alberto Martin

http://www.w3.org/2001/XMLSchema#string

Anat Kapelnikov

http://www.w3.org/2001/XMLSchema#string

Diana Ronai

http://www.w3.org/2001/XMLSchema#string

Jahan-Yar Parsa

http://www.w3.org/2001/XMLSchema#string

Maribel Berru

http://www.w3.org/2001/XMLSchema#string

Rajeev M Nepal

http://www.w3.org/2001/XMLSchema#string

Shaliny Ramachandran

http://www.w3.org/2001/XMLSchema#string

P2860

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates

Somatic hypermutation of the AID transgene in B and non-B cells

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

RNA polymerase and transcription elongation factor Spt4/5 complex structure.

Architecture of the RNA polymerase-Spt4/5 complex and basis of universal transcription processivity

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination

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e1002518

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scholarly article

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10.1371/JOURNAL.PGEN.1002518

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2

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8

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Antoaneta Belcheva

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2012-02-09T00:00:00Z

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221844169

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22346767

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3276561

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