The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.
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Targeting p97 to Disrupt Protein Homeostasis in CancerRing of Change: CDC48/p97 Drives Protein Dynamics at ChromatinAutophagy and Neurodegeneration: Insights from a Cultured Cell Model of ALSInsights into muscle degeneration from heritable inclusion body myopathiesCardiac-Restricted Expression of VCP/TER94 RNAi or Disease Alleles Perturbs Drosophila Heart Structure and Impairs Function.Mutations in the Human AAA+ Chaperone p97 and Related DiseasesControl of p97 function by cofactor bindingDendrimer-Based Selective Proteostasis-Inhibition Strategy to Control NSCLC Growth and ProgressionVCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy.The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97.Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia ContinuumSelective inhibition of p97 by chlorinated analogues of dehydrocurvularinA Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.Sequestration of cellular interacting partners by protein aggregates: implication in a loss-of-function pathology.Granulostasis: Protein Quality Control of RNP Granules.Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor κB (NF-κB) signalingInhibitors of the AAA+ chaperone p97Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice.The host ubiquitin-dependent segregase VCP/p97 is required for the onset of human cytomegalovirus replication.Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxinp97/VCP promotes Cullin-RING-ubiquitin-ligase/proteasome-dependent degradation of IκBα and the preceding liberation of RelA from ubiquitinated IκBα.Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain.Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines.The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradationStructure and function of the AAA+ ATPase p97/Cdc48p.p97 Composition Changes Caused by Allosteric Inhibition Are Suppressed by an On-Target Mechanism that Increases the Enzyme's ATPase Activity.Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response.Rare variants in SQSTM1 and VCP genes and risk of sporadic inclusion body myositisA Dynamic molecular basis for malfunction in disease mutants of p97/VCP.p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein-Protein Interactions.Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants.Prions and Protein Assemblies that Convey Biological Information in Health and Disease.Pch2(TRIP13): controlling cell division through regulation of HORMA domains.Sporadic inclusion body myositis - a myodegenerative disease or an inflammatory myopathy.Genetics of FTLD: overview and what else we can expect from genetic studies.Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication.Principles and Properties of Stress GranulesUbiquitin-dependent and independent roles of SUMO in proteostasis.
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The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.
description
2014 nî lūn-bûn
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2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
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name
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.
@ast
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.
@en
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.
@nl
type
label
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.
@ast
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.
@en
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.
@nl
prefLabel
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.
@ast
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.
@en
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.
@nl
P2860
P356
P1476
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis
@en
P2093
Conrad C Weihl
P2860
P304
P356
10.1242/JCS.093831
P407
P577
2014-08-21T00:00:00Z