A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.
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Recent developments in using mechanistic cardiac modelling for drug safety evaluationModeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety AssessmentCalcium and IP3 dynamics in cardiac myocytes: experimental and computational perspectives and approachesThree-dimensional computer model of the right atrium including the sinoatrial and atrioventricular nodes predicts classical nodal behavioursNumerical analysis of Ca2+ signaling in rat ventricular myocytes with realistic transverse-axial tubular geometry and inhibited sarcoplasmic reticulumGenetic evidence in the mouse solidifies the calcium hypothesis of myofiber death in muscular dystrophyA Mathematical Model of Neonatal Rat Atrial Monolayers with Constitutively Active Acetylcholine-Mediated K+ CurrentThe catecholaminergic polymorphic ventricular tachycardia mutation R33Q disrupts the N-terminal structural motif that regulates reversible calsequestrin polymerizationPrediction of Thorough QT study results using action potential simulations based on ion channel screensPopulation of computational rabbit-specific ventricular action potential models for investigating sources of variability in cellular repolarisationLife and death of a cardiac calcium sparkSimulation and mechanistic investigation of the arrhythmogenic role of the late sodium current in human heart failurePhospholemman is a negative feed-forward regulator of Ca2+ in β-adrenergic signaling, accelerating β-adrenergic inotropy.Calmodulin binding proteins provide domains of local Ca2+ signaling in cardiac myocytesSynergy between CaMKII substrates and β-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling.Efficient simulation of cardiac electrical propagation using high order finite elements.Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytesDifferential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets.Mathematical model of mouse embryonic cardiomyocyte excitation-contraction coupling.Modeling effects of L-type ca(2+) current and na(+)-ca(2+) exchanger on ca(2+) trigger flux in rabbit myocytes with realistic T-tubule geometriesHierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells.Evaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge.Integrating multi-scale data to create a virtual physiological mouse heart.Microdomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart Failure.Ionic mechanisms for electrical heterogeneity between rabbit Purkinje fiber and ventricular cells.Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization.Regression analysis for constraining free parameters in electrophysiological models of cardiac cells.Cardiovascular networks: systems-based approaches to cardiovascular diseaseA computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current.Impact of sarcoplasmic reticulum calcium release on calcium dynamics and action potential morphology in human atrial myocytes: a computational study.Models of cardiac excitation-contraction coupling in ventricular myocytesPredicting local SR Ca(2+) dynamics during Ca(2+) wave propagation in ventricular myocytes.A computational model of the ionic currents, Ca2+ dynamics and action potentials underlying contraction of isolated uterine smooth muscle.A novel quantitative explanation for the autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteins.Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporterSystems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary.Distribution of electromechanical delay in the heart: insights from a three-dimensional electromechanical model.Junctional cleft [Ca²⁺]i measurements using novel cleft-targeted Ca²⁺ sensorsRole of CaMKII in RyR leak, EC coupling and action potential duration: a computational model.Data-based theoretical identification of subcellular calcium compartments and estimation of calcium dynamics in cardiac myocytes.
P2860
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P2860
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.
description
2004 nî lūn-bûn
@nan
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.
@ast
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.
@en
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.
@nl
type
label
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.
@ast
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.
@en
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.
@nl
prefLabel
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.
@ast
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.
@en
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.
@nl
P2093
P2860
P1433
P1476
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte
@en
P2093
Donald M Bers
José Puglisi
Thomas R Shannon
P2860
P304
P356
10.1529/BIOPHYSJ.104.047449
P407
P577
2004-09-03T00:00:00Z