Phylomedicine: an evolutionary telescope to explore and diagnose the universe of disease mutations.
about
Evolutionary analysis of selective constraints identifies ameloblastin (AMBN) as a potential candidate for amelogenesis imperfectaA Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3,000 Cancer Genomes across 9 Cancer TypesMolecular evolution of the tissue-nonspecific alkaline phosphatase allows prediction and validation of missense mutations responsible for hypophosphatasiaA phylomedicine approach to understanding the evolution of auditory sensory perception and disease in mammalsBioinformatics for personal genome interpretationAn association-adjusted consensus deleterious scheme to classify homozygous Mis-sense mutations for personal genome interpretationConformational dynamics of nonsynonymous variants at protein interfaces reveals disease association.Comparative sequence analyses of rhodopsin and RPE65 reveal patterns of selective constraint across hereditary retinal disease mutations.Structural dynamics flexibility informs function and evolution at a proteome scale.Properties of human disease genes and the role of genes linked to Mendelian disorders in complex disease aetiology.Evolutionary Analysis Predicts Sensitive Positions of MMP20 and Validates Newly- and Previously-Identified MMP20 Mutations Causing Amelogenesis ImperfectaStudying tumorigenesis through network evolution and somatic mutational perturbations in the cancer interactomeEvolutionary meta-analysis of association studies reveals ancient constraints affecting disease marker discovery.The genomic signature of trait-associated variants.The evolutionary history of amino acid variations mediating increased resistance of S. aureus identifies reversion mutations in metabolic regulatorsWhole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary history.Adaptive Evolution as a Predictor of Species-Specific Innate Immune Response.Human genomic disease variants: a neutral evolutionary explanation.Performance of computational tools in evaluating the functional impact of laboratory-induced amino acid mutationse-GRASP: an integrated evolutionary and GRASP resource for exploring disease associationsUsing Disease-Associated Coding Sequence Variation to Investigate Functional Compensation by Human Paralogous Proteins.Evolutionary balancing is critical for correctly forecasting disease-associated amino acid variants.Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genesAssociation of genetic variation in the mitochondrial genome with blood pressure and metabolic traits.Phylogenetic Gaussian process model for the inference of functionally important regions in protein tertiary structures.Next-generation sequencing for mitochondrial disordersMEGA-MD: molecular evolutionary genetics analysis software with mutational diagnosis of amino acid variation.Recent approaches to the prioritization of candidate disease genes.Integration of structural dynamics and molecular evolution via protein interaction networks: a new era in genomic medicine.Genomic insights into ayurvedic and western approaches to personalized medicine.Evolution-informed modeling improves outcome prediction for cancers.The Role of Conformational Dynamics and Allostery in the Disease Development of Human Ferritin.A Bayesian ensemble approach with a disease gene network predicts damaging effects of missense variants of human cancers.DFNB16 is a frequent cause of congenital hearing impairment: implementation of STRC mutation analysis in routine diagnosticsAn improved hypergeometric probability method for identification of functionally linked proteins using phylogenetic profiles.Substitutions into amino acids that are pathogenic in human mitochondrial proteins are more frequent in lineages closely related to human than in distant lineages.Feature-based classification of amino acid substitutions outside conserved functional protein domains.Earth BioGenome Project: Sequencing life for the future of life.Helminths and Cancers From the Evolutionary Perspective.
P2860
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P2860
Phylomedicine: an evolutionary telescope to explore and diagnose the universe of disease mutations.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Phylomedicine: an evolutionary ...... universe of disease mutations.
@ast
Phylomedicine: an evolutionary ...... universe of disease mutations.
@en
Phylomedicine: an evolutionary ...... universe of disease mutations.
@nl
type
label
Phylomedicine: an evolutionary ...... universe of disease mutations.
@ast
Phylomedicine: an evolutionary ...... universe of disease mutations.
@en
Phylomedicine: an evolutionary ...... universe of disease mutations.
@nl
prefLabel
Phylomedicine: an evolutionary ...... universe of disease mutations.
@ast
Phylomedicine: an evolutionary ...... universe of disease mutations.
@en
Phylomedicine: an evolutionary ...... universe of disease mutations.
@nl
P2093
P2860
P1433
P1476
Phylomedicine: an evolutionary ...... universe of disease mutations.
@en
P2093
Alan Filipski
Joel T Dudley
P2860
P304
P356
10.1016/J.TIG.2011.06.004
P50
P577
2011-07-20T00:00:00Z