Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.
about
Role of the Retromer Complex in Neurodegenerative DiseasesGolgi fragmentation in Alzheimer's diseaseThe endosomal-lysosomal system: from acidification and cargo sorting to neurodegenerationDysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseasesA Genetic Variant of the Sortilin 1 Gene is Associated with Reduced Risk of Alzheimer's DiseaseAngiotensin II mediates angiotensin converting enzyme type 2 internalization and degradation through an angiotensin II type I receptor-dependent mechanism.Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor proteinAn aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase.LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking(1,2,3).Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neuronsDeficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme 1.Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity.5-Amino-oxazepine and 5-Amino-thiazepine Compounds as β-Secretase Antagonists and Methods of Use: Patent Highlight.Cyclopropyl-Fused 1,3-Thiazepines as BACE1 and BACE2 Inhibitors.Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processingThe polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb.Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1.Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases.BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease.Potential Effects of MSC-Derived Exosomes in Neuroplasticity in Alzheimer's Disease
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P2860
Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.
@ast
Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.
@en
Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.
@nl
type
label
Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.
@ast
Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.
@en
Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.
@nl
prefLabel
Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.
@ast
Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.
@en
Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.
@nl
P2860
P1476
Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.
@en
P2093
Geneviève Evin
Jiangli Tan
P2860
P304
P356
10.1111/J.1471-4159.2011.07623.X
P407
P577
2012-01-23T00:00:00Z