A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset. - sprookjes - yvandenbroek - TriplyDB

A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset.

A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset.

http://www.wikidata.org/entity/Q34275231

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Epigenetic Modifications of the PGC-1α Promoter during Exercise Induced Expression in Mice A Novel Analytical Strategy to Identify Fusion Transcripts between Repetitive Elements and Protein Coding-Exons Using RNA-Seq Metabolism in HD: still a relevant mechanism?Population stratification may bias analysis of PGC-1α as a modifier of age at Huntington disease motor onset.Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1α.PGC-1α regulation of mitochondrial degeneration in experimental diabetic neuropathy.Comparison of Sirtuin 3 Levels in ALS and Huntington's Disease-Differential Effects in Human Tissue Samples vs. Transgenic Mouse Models.Expression of PGC1α in glioblastoma multiforme patients.Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf.Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization A single nucleotide polymorphism in the coding region of PGC-1α is a male-specific modifier of Huntington disease age-at-onset in a large European cohort.Associations of Haplotypes Upstream of IRS1 with Insulin Resistance, Type 2 Diabetes, Dyslipidemia, Preclinical Atherosclerosis, and Skeletal Muscle LOC646736 mRNA Levels Potential roles of PINK1 for increased PGC-1α-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes.A novel PGC-1α isoform in brain localizes to mitochondria and associates with PINK1 and VDAC.Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons.Foxa1 is essential for development and functional integrity of the subthalamic nucleus.β-Defensin Genomic Copy Number Does Not Influence the Age of Onset in Huntington's Disease.Prospects for neuroprotective therapies in prodromal Huntington's disease.Genetic modifiers of Huntington's disease.Regulation of PGC-1α Isoform Expression in Skeletal Muscles.The hitchhiker's guide to PGC-1α isoform structure and biological functions.Current disease modifying approaches to treat Parkinson's disease.Huntington's Disease: Relationship Between Phenotype and Genotype.Peroxisome proliferator-activated receptor-γ coactivator-1α mediates neuroprotection against excitotoxic brain injury in transgenic mice: role of mitochondria and X-linked inhibitor of apoptosis protein.Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington's disease.Transcriptional coactivator NT-PGC-1α promotes gluconeogenic gene expression and enhances hepatic gluconeogenesis.Decreased mRNA expression of PGC-1α and PGC-1α-regulated factors in the SOD1G93A ALS mouse model and in human sporadic ALS.mRNA expression levels of PGC-1α in a transgenic and a toxin model of Huntington's disease.PPARGC1A and ADIPOQ polymorphisms are associated with aggressive prostate cancer in Mexican-Mestizo men with overweight or obesity.Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons.Overexpression of PGC-1α Influences Mitochondrial Signal Transduction of Dopaminergic Neurons.Exercise-induced expression of peroxisome proliferator-activated receptor γ coactivator-1α isoforms in skeletal muscle of endurance-trained males.Transcriptional Dysregulation and Post-translational Modifications in Polyglutamine Diseases: From Pathogenesis to Potential Therapeutic Strategies.

P2860

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P2860

A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset.

http://www.wikidata.org/entity/Q34275231

description

2012 nî lūn-bûn

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2012 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2012 թվականի մայիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

A greatly extended PPARGC1A ge ...... ntington disease age of onset.

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A greatly extended PPARGC1A ge ...... ntington disease age of onset.

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A greatly extended PPARGC1A ge ...... ntington disease age of onset.

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A greatly extended PPARGC1A ge ...... ntington disease age of onset.

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A greatly extended PPARGC1A ge ...... ntington disease age of onset.

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A greatly extended PPARGC1A ge ...... ntington disease age of onset.

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A greatly extended PPARGC1A ge ...... ntington disease age of onset.

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A greatly extended PPARGC1A ge ...... ntington disease age of onset.

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A greatly extended PPARGC1A ge ...... ntington disease age of onset.

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Human Molecular Genetics

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A greatly extended PPARGC1A ge ...... ntington disease age of onset.

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Anke Witting

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European Huntington Disease Network

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G Bernhard Landwehrmeyer

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Hannes Oberkofler

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Markus Paulmichl

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Patrick Weydt

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Penelope Hahne

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Selma M Soyal

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Simon Auer

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Wolfgang Patsch

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P2860

Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression

Z-DNA-binding proteins can act as potent effectors of gene expression in vivo.

A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen

PGC-1, a versatile coactivator

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo

Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells

ExPASy: The proteomics server for in-depth protein knowledge and analysis

The human genome browser at UCSC

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3461-3473

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10.1093/HMG/DDS177

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15

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21

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Markus Paulmichl

Thomas K Felder

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2012-05-15T00:00:00Z

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224966460

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22589246

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Huntington disease