Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation.
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Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymesStructures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substratesThe critical role of substrate-protein hydrogen bonding in the control of regioselective hydroxylation in p450cinCrystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeletonProton delivery in NO reduction by fungal nitric-oxide reductase. Cryogenic crystallography, spectroscopy, and kinetics of ferric-NO complexes of wild-type and mutant enzymesCrystal structure of OxyB, a cytochrome P450 implicated in an oxidative phenol coupling reaction during vancomycin biosynthesisCrystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoKProbing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteineStructure of Cytochrome P450 PimD Suggests Epoxidation of the Polyene Macrolide Pimaricin Occurs via a Hydroperoxoferric IntermediateActive Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/ o -Xylene Monooxygenase HydroxylaseP450cin Active Site Water: Implications for Substrate Binding and Solvent AccessibilityVariations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamilyEvaluation of influence of single nucleotide polymorphisms in cytochrome P450 2B6 on substrate recognition using computational docking and molecular dynamics simulationMechanistic aspects of CYP74 allene oxide synthases and related cytochrome P450 enzymesMolecular cloning and characterization of CYP719, a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, from cultured Coptis japonica cells.Proximal cysteine residue is essential for the enzymatic activities of cytochrome P450cam.Kinetics of oxidation of benzphetamine by compounds I of cytochrome P450 2B4 and its mutants.Revisiting the mechanism of dioxygen activation in soluble methane monooxygenase from M. capsulatus (Bath): evidence for a multi-step, proton-dependent reaction pathway.Coupling and uncoupling mechanisms in the methoxythreonine mutant of cytochrome P450cam: a quantum mechanical/molecular mechanical study.Molecular cloning of a cDNA encoding aldosterone synthase cytochrome P-450 in rat adrenal cortex.Spin equilibrium and O₂-binding kinetics of Mycobacterium tuberculosis CYP51 with mutations in the histidine-threonine dyadCloning, sequencing, and characterization of the hexahydro-1,3,5-Trinitro-1,3,5-triazine degradation gene cluster from Rhodococcus rhodochrous.Enzyme ingenuity in biological oxidations: a trail leading to cytochrome p450.Alkaloid Biosynthesis[mdash]The Basis for Metabolic Engineering of Medicinal Plants.Changing the regioselectivity of a P450 from C15 to C11 hydroxylation of progesterone.Spectroscopic and kinetic studies on reaction of cytochrome P450nor with nitric oxide. Implication for its nitric oxide reduction mechanism.Heme enzyme structure and function.Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer.Epoxidation of olefins by cytochrome P450: evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant.Targeting of the highly conserved threonine 302 residue of cytochromes P450 2B family during mechanism-based inactivation by aryl acetylenesA numerically stable restrained electrostatic potential charge fitting method.Molecular cloning and heterologous expression of a cDNA encoding berbamunine synthase, a C--O phenol-coupling cytochrome P450 from the higher plant Berberis stoloniferaAge-related effects of heat stress on protective enzymes for peroxides and microsomal monooxygenase in rat liver.Formation of two methylenedioxy bridges by a Sesamum CYP81Q protein yielding a furofuran lignan, (+)-sesamin.N-oxidative transformation of free and N-substituted amine functions by cytochrome P450 as means of bioactivation and detoxication.The role of copper and protons in heme-copper oxidases: kinetic study of an engineered heme-copper center in myoglobin.New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.Mechanistic enzymology of oxygen activation by the cytochromes P450.Degradation of the thiocarbamate herbicide EPTC (S-ethyl dipropylcarbamothioate) and biosafening by Rhodococcus sp. strain NI86/21 involve an inducible cytochrome P-450 system and aldehyde dehydrogenase.Determination of target sequence bound by PapX, repressor of bacterial motility, in flhD promoter using systematic evolution of ligands by exponential enrichment (SELEX) and high throughput sequencing.
P2860
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P2860
Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation.
description
1989 nî lūn-bûn
@nan
1989 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Uncoupling of the cytochrome P ...... ino acid in oxygen activation.
@ast
Uncoupling of the cytochrome P ...... ino acid in oxygen activation.
@en
Uncoupling of the cytochrome P ...... ino acid in oxygen activation.
@nl
type
label
Uncoupling of the cytochrome P ...... ino acid in oxygen activation.
@ast
Uncoupling of the cytochrome P ...... ino acid in oxygen activation.
@en
Uncoupling of the cytochrome P ...... ino acid in oxygen activation.
@nl
prefLabel
Uncoupling of the cytochrome P ...... ino acid in oxygen activation.
@ast
Uncoupling of the cytochrome P ...... ino acid in oxygen activation.
@en
Uncoupling of the cytochrome P ...... ino acid in oxygen activation.
@nl
P2093
P2860
P356
P1476
Uncoupling of the cytochrome P ...... ino acid in oxygen activation.
@en
P2093
Horiuchi T
Ishimura Y
Matsushima-Hibiya Y
Watanabe Y
P2860
P304
P356
10.1073/PNAS.86.20.7823
P407
P577
1989-10-01T00:00:00Z