Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells
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Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with ageMechanism of microhomology-mediated end-joining promoted by human DNA polymerase θMechanisms of Origin, Phenotypic Effects and Diagnostic Implications of Complex Chromosome RearrangementsATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to AdaptorThe role of RecQ helicases in non-homologous end-joiningImproving the efficacy of chemoradiation with targeted agentsReplication protein A prevents promiscuous annealing between short sequence homologies: Implications for genome integrityChoices have consequences: the nexus between DNA repair pathways and genomic instability in cancerBalancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?DNA Polymerase θ: A Unique Multifunctional End-Joining MachineReplication fork instability and the consequences of fork collisions from rereplicationNoncanonical views of homology-directed DNA repairMicrohomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?MRE11-deficiency associated with improved long-term disease free survival and overall survival in a subset of stage III colon cancer patients in randomized CALGB 89803 trialHomology and enzymatic requirements of microhomology-dependent alternative end joiningBRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous RecombinationmiR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB RepairMicrohomology-mediated end joining: new players join the teamMammalian polymerase θ promotes alternative NHEJ and suppresses recombinationDouble strand break repair functions of histone H2AXMechanisms and Consequences of Double-Strand DNA Break Formation in ChromatinWRN regulates pathway choice between classical and alternative non-homologous end joiningMicrohomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex.Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions.A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining.Drugging the Cancers Addicted to DNA Repair.Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repairEnd resection at double-strand breaks: mechanism and regulation.Ku-mediated coupling of DNA cleavage and repair during programmed genome rearrangements in the ciliate Paramecium tetraurelia.DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cellsHomologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplicationSVA retrotransposon insertion-associated deletion represents a novel mutational mechanism underlying large genomic copy number changes with non-recurrent breakpoints.RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks.53BP1 promotes microhomology-mediated end-joining in G1-phase cells.RPA antagonizes microhomology-mediated repair of DNA double-strand breaks.Analysis of the role of homology arms in gene-targeting vectors in human cellsDNA end resection is needed for the repair of complex lesions in G1-phase human cells.Identification of novel radiosensitizers in a high-throughput, cell-based screen for DSB repair inhibitors.DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining.
P2860
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P2860
Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells
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2013 nî lūn-bûn
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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2013 թվականի ապրիլին հրատարակված գիտական հոդված
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2013年の論文
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2013年学术文章
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Microhomology-mediated End Joi ...... rand breaks in mammalian cells
@ast
Microhomology-mediated End Joi ...... rand breaks in mammalian cells
@en
Microhomology-mediated End Joi ...... rand breaks in mammalian cells
@nl
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Microhomology-mediated End Joi ...... rand breaks in mammalian cells
@ast
Microhomology-mediated End Joi ...... rand breaks in mammalian cells
@en
Microhomology-mediated End Joi ...... rand breaks in mammalian cells
@nl
prefLabel
Microhomology-mediated End Joi ...... rand breaks in mammalian cells
@ast
Microhomology-mediated End Joi ...... rand breaks in mammalian cells
@en
Microhomology-mediated End Joi ...... rand breaks in mammalian cells
@nl
P2093
P2860
P356
P1476
Microhomology-mediated End Joi ...... rand breaks in mammalian cells
@en
P2093
Hailong Wang
Lan N Truong
Linda Z Shi
Michael W Berns
Niema Razavian
Patty Yi-Hwa Hwang
Xiaohua Wu
Yongjiang Li
P2860
P304
P356
10.1073/PNAS.1213431110
P407
P577
2013-04-22T00:00:00Z