IKAROS deletions dictate a unique gene expression signature in patients with adult B-cell acute lymphoblastic leukemia
about
Current concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemiaUse of single nucleotide polymorphism array technology to improve the identification of chromosomal lesions in leukemiaLoss of B Cells in Patients with Heterozygous Mutations in IKAROS.Novel gene targets detected by genomic profiling in a consecutive series of 126 adults with acute lymphoblastic leukemia.Constitutive function of the Ikaros transcription factor in primary leukemia cells from pediatric newly diagnosed high-risk and relapsed B-precursor ALL patients.Expression of Ik6 and Ik8 Isoforms and Their Association with Relapse and Death in Mexican Children with Acute Lymphoblastic LeukemiaFunction of Ikaros as a tumor suppressor in B cell acute lymphoblastic leukemiaRecurrent deletions of IKZF1 in pediatric acute myeloid leukemiaEpigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia.Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.Transcriptional regulation of the Ikzf1 locus.Targeting of heme oxygenase-1 attenuates the negative impact of Ikaros isoform 6 in adult BCR-ABL1-positive B-ALL.Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells.Ikaros and leukaemia.The BET bromodomain inhibitor CPI203 improves lenalidomide and dexamethasone activity in in vitro and in vivo models of multiple myeloma by blockade of Ikaros and MYC signaling.Effect of IKZF1 deletions on signal transduction pathways in Philadelphia chromosome negative pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL).Dominant-negative Ikaros cooperates with BCR-ABL1 to induce human acute myeloid leukemia in xenografts.Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia.Impact of IKZF1 deletions on long-term outcomes of allo-SCT following imatinib-based chemotherapy in adult Philadelphia chromosome-positive ALL.Lenalidomide, an antiproliferative CLL drug.Therapeutic potential of spleen tyrosine kinase inhibition for treating high-risk precursor B cell acute lymphoblastic leukemia.Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia.Possible implication of IKAROS gene deletion and BCR-ABL1 variants in progression of chronic myeloid leukemia to lymphoid blast crisis in childhood: a single-institution experience.The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia.IMiD compounds affect CD34 cell fate and maturation via CRBN-induced IKZF1 degradation
P2860
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P2860
IKAROS deletions dictate a unique gene expression signature in patients with adult B-cell acute lymphoblastic leukemia
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
IKAROS deletions dictate a uni ...... l acute lymphoblastic leukemia
@ast
IKAROS deletions dictate a uni ...... l acute lymphoblastic leukemia
@en
IKAROS deletions dictate a uni ...... l acute lymphoblastic leukemia
@nl
type
label
IKAROS deletions dictate a uni ...... l acute lymphoblastic leukemia
@ast
IKAROS deletions dictate a uni ...... l acute lymphoblastic leukemia
@en
IKAROS deletions dictate a uni ...... l acute lymphoblastic leukemia
@nl
prefLabel
IKAROS deletions dictate a uni ...... l acute lymphoblastic leukemia
@ast
IKAROS deletions dictate a uni ...... l acute lymphoblastic leukemia
@en
IKAROS deletions dictate a uni ...... l acute lymphoblastic leukemia
@nl
P2093
P2860
P50
P1433
P1476
IKAROS deletions dictate a uni ...... l acute lymphoblastic leukemia
@en
P2093
Anna Ferrari
Antonella Vitale
Francesca Paoloni
Giovanni Perini
Markus Müschen
Sabina Chiaretti
Viviana Guadagnuolo
P2860
P304
P356
10.1371/JOURNAL.PONE.0040934
P407
P50
P577
2012-07-25T00:00:00Z