Mapping of functional regions in the amino-terminal portion of the herpes simplex virus ICP27 regulatory protein: importance of the leucine-rich nuclear export signal and RGG Box RNA-binding domain.
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Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathwaysHerpes simplex virus type 1 immediate-early protein ICP27 is required for efficient incorporation of ICP0 and ICP4 into virionsHerpes simplex virus dances with amyloid precursor protein while exiting the cellStructural Basis for the Recognition of Cellular mRNA Export Factor REF by Herpes Viral Proteins HSV-1 ICP27 and HVS ORF57Identification of herpes simplex virus RNAs that interact specifically with regulatory protein ICP27 in vivo.Hsc70 focus formation at the periphery of HSV-1 transcription sites requires ICP27.ICP27 phosphorylation site mutants are defective in herpes simplex virus 1 replication and gene expression.ICP27 phosphorylation site mutants display altered functional interactions with cellular export factors Aly/REF and TAP/NXF1 but are able to bind herpes simplex virus 1 RNAICP27 recruits Aly/REF but not TAP/NXF1 to herpes simplex virus type 1 transcription sites although TAP/NXF1 is required for ICP27 export.Control of VP16 translation by the herpes simplex virus type 1 immediate-early protein ICP27.Herpes simplex virus 1 regulatory protein ICP27 undergoes a head-to-tail intramolecular interaction.Herpes simplex virus ICP27 activation of stress kinases JNK and p38.ICP27 interacts with the C-terminal domain of RNA polymerase II and facilitates its recruitment to herpes simplex virus 1 transcription sites, where it undergoes proteasomal degradation during infection.Arginine methylation of the RGG box does not appear to regulate ICP27 import during herpes simplex virus infection.Herpes simplex virus ICP27 is required for virus-induced stabilization of the ARE-containing IEX-1 mRNA encoded by the human IER3 geneIdentification of nuclear and nucleolar localization signals of pseudorabies virus (PRV) early protein UL54 reveals that its nuclear targeting is required for efficient production of PRV.Herpes simplex virus ICP27 increases translation of a subset of viral late mRNAs.Herpes simplex virus type 1 ICP27 regulates expression of a variant, secreted form of glycoprotein C by an intron retention mechanism.The interaction of the cellular export adaptor protein Aly/REF with ICP27 contributes to the efficiency of herpes simplex virus 1 mRNA export.Efficient nuclear export of herpes simplex virus 1 transcripts requires both RNA binding by ICP27 and ICP27 interaction with TAP/NXF1Herpes simplex virus type 1 ICP27 induces p38 mitogen-activated protein kinase signaling and apoptosis in HeLa cells.Role of immediate early protein ICP27 in the differential sensitivity of herpes simplex viruses 1 and 2 to leptomycin BArginine methylation of the ICP27 RGG box regulates ICP27 export and is required for efficient herpes simplex virus 1 replication.Mutation of a C-terminal motif affects Kaposi's sarcoma-associated herpesvirus ORF57 RNA binding, nuclear trafficking, and multimerization.Functional comparison of herpes simplex virus 1 (HSV-1) and HSV-2 ICP27 homologs reveals a role for ICP27 in virion release.Herpes simplex virus type 1 ICP27-dependent activation of NF-kappaB.Nucleocytoplasmic shuttling of human cytomegalovirus UL84 is essential for virus growth.RNA binding by the herpes simplex virus type 1 nucleocytoplasmic shuttling protein UL47 is mediated by an N-terminal arginine-rich domain that also functions as its nuclear localization signal.SR proteins SRp20 and 9G8 contribute to efficient export of herpes simplex virus 1 mRNAs.Nucleocytoplasmic shuttling of bovine herpesvirus 1 UL47 protein in infected cells.The evolutionarily conserved Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with REF protein and acts as an RNA export factor.Viral regulation of mRNA export.Phenotypic suppression of a herpes simplex virus 1 ICP27 mutation by enhanced transcription of the mutant gene.Identification of an ICP27-responsive element in the coding region of a herpes simplex virus type 1 late gene.
P2860
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P2860
Mapping of functional regions in the amino-terminal portion of the herpes simplex virus ICP27 regulatory protein: importance of the leucine-rich nuclear export signal and RGG Box RNA-binding domain.
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Mapping of functional regions ...... nd RGG Box RNA-binding domain.
@ast
Mapping of functional regions ...... nd RGG Box RNA-binding domain.
@en
Mapping of functional regions ...... nd RGG Box RNA-binding domain.
@nl
type
label
Mapping of functional regions ...... nd RGG Box RNA-binding domain.
@ast
Mapping of functional regions ...... nd RGG Box RNA-binding domain.
@en
Mapping of functional regions ...... nd RGG Box RNA-binding domain.
@nl
prefLabel
Mapping of functional regions ...... nd RGG Box RNA-binding domain.
@ast
Mapping of functional regions ...... nd RGG Box RNA-binding domain.
@en
Mapping of functional regions ...... nd RGG Box RNA-binding domain.
@nl
P2093
P2860
P1433
P1476
Mapping of functional regions ...... nd RGG Box RNA-binding domain.
@en
P2093
Chandra Guy
Joy Lengyel
Sarah Borge
Stephen A Rice
Vivian Leong
P2860
P304
11866-11879
P356
10.1128/JVI.76.23.11866-11879.2002
P407
P577
2002-12-01T00:00:00Z