Resolution of the mammalian E complex and the ATP-dependent spliceosomal complexes on native agarose mini-gels
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Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicingProtein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP formation and pre-mRNA splicing.A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicingProteins associated with the exon junction complex also control the alternative splicing of apoptotic regulatorsThe U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicingDistinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosomeTissue-specific splicing regulator Fox-1 induces exon skipping by interfering E complex formation on the downstream intron of human F1gamma geneContribution of DEAH-box protein DHX16 in human pre-mRNA splicingIdentification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.Retroviral splicing suppressor sequesters a 3' splice site in a 50S aberrant splicing complex.The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster.Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors.Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1.Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.Modified nucleotides at the 5' end of human U2 snRNA are required for spliceosomal E-complex formation.An artificial riboswitch for controlling pre-mRNA splicing.The RNA binding motif protein 15B (RBM15B/OTT3) is a functional competitor of serine-arginine (SR) proteins and antagonizes the positive effect of the CDK11p110-cyclin L2α complex on splicing.G Run-mediated recognition of proteolipid protein and DM20 5' splice sites by U1 small nuclear RNA is regulated by context and proximity to the splice site.The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region.Functional coupling of RNAP II transcription to spliceosome assemblySynthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNAGPKOW is essential for pre-mRNA splicing in vitro and suppresses splicing defect caused by dominant-negative DHX16 mutation in vivo.A high-throughput splicing assay identifies new classes of inhibitors of human and yeast spliceosomesStalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation.Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly.Intron retention in the alternatively spliced region of RON results from weak 3' splice site recognition.The polypyrimidine tract binding protein (PTB) represses splicing of exon 6B from the beta-tropomyosin pre-mRNA by directly interfering with the binding of the U2AF65 subunitRBFOX2 promotes protein 4.1R exon 16 selection via U1 snRNP recruitment.The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human SpliceosomesFUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNPNuclear cyclophilins affect spliceosome assembly and function in vitro.ATPγS stalls splicing after B complex formation but prior to spliceosome activation.Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms.Splicing is required for rapid and efficient mRNA export in metazoans.Human immunodeficiency virus type 1 hnRNP A/B-dependent exonic splicing silencer ESSV antagonizes binding of U2AF65 to viral polypyrimidine tracts.Spliceosome assembly pathways for different types of alternative splicing converge during commitment to splice site pairing in the A complex.Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator.A role for TREX components in the release of spliced mRNA from nuclear speckle domains.The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing.
P2860
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P2860
Resolution of the mammalian E complex and the ATP-dependent spliceosomal complexes on native agarose mini-gels
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Resolution of the mammalian E ...... es on native agarose mini-gels
@ast
Resolution of the mammalian E ...... es on native agarose mini-gels
@en
Resolution of the mammalian E ...... es on native agarose mini-gels
@nl
type
label
Resolution of the mammalian E ...... es on native agarose mini-gels
@ast
Resolution of the mammalian E ...... es on native agarose mini-gels
@en
Resolution of the mammalian E ...... es on native agarose mini-gels
@nl
prefLabel
Resolution of the mammalian E ...... es on native agarose mini-gels
@ast
Resolution of the mammalian E ...... es on native agarose mini-gels
@en
Resolution of the mammalian E ...... es on native agarose mini-gels
@nl
P2860
P1433
P1476
Resolution of the mammalian E ...... es on native agarose mini-gels
@en
P2860
P304
P356
10.1017/S1355838299991501
P407
P577
1999-11-01T00:00:00Z