Genome-wide mutational signatures of aristolochic acid and its application as a screening tool.
about
Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advancesThe Potential Power of Bar-HRM Technology in Herbal Medicine IdentificationGenomics of Cancer and a New Era for Cancer PreventionChinese herbs containing aristolochic acid associated with renal failure and urothelial carcinoma: a review from epidemiologic observations to causal inferenceBalkan endemic nephropathy: an update on its aetiologyHypermutation in human cancer genomes: footprints and mechanismsMutational signatures of ionizing radiation in second malignanciesMechanisms of enzyme-catalyzed reduction of two carcinogenic nitro-aromatics, 3-nitrobenzanthrone and aristolochic acid I: Experimental and theoretical approachesAristolochic acid exposure in Romania and implications for renal cell carcinomaComparison of hepatocellular carcinoma in Eastern versus Western populations.Base changes in tumour DNA have the power to reveal the causes and evolution of cancer.Carcinogen-specific mutations in preferred Ras-Raf pathway oncogenes directed by strand bias.Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance.Modelling mutational landscapes of human cancers in vitro.NGS nominated CELA1, HSPG2, and KCNK5 as candidate genes for predisposition to Balkan endemic nephropathyMutation signatures of carcinogen exposure: genome-wide detection and new opportunities for cancer prevention.Mutational signature of aristolochic acid exposure as revealed by whole-exome sequencing.Developing traditional chinese medicine in the era of evidence-based medicine: current evidences and challenges.Mutation signatures implicate aristolochic acid in bladder cancer developmentAPOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity.An integrated system for identifying the hidden assassins in traditional medicines containing aristolochic acids.MutSpec: a Galaxy toolbox for streamlined analyses of somatic mutation spectra in human and mouse cancer genomes.Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B.New Approaches for Biomonitoring Exposure to the Human Carcinogen Aristolochic Acid.The PKC/NF-κB signaling pathway induces APOBEC3B expression in multiple human cancers.A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches.Genomic approaches to DNA repair and mutagenesis.Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid.Activity of Aristolochia bracteolata against Moraxella catarrhalisActive Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivoLow-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid.Aristolochic acid, a plant extract used in the treatment of pain and linked to Balkan endemic nephropathy, is a regulator of K2P channels.A comprehensive survey of the mutagenic impact of common cancer cytotoxicsRapid Identification of Officinal Akebiae Caulis and Its Toxic Adulterant Aristolochiae Manshuriensis Caulis (Aristolochia manshuriensis) by Loop-Mediated Isothermal Amplification.5-hydroxymethylcytosine marks regions with reduced mutation frequency in human DNASulfotransferase-1A1-dependent bioactivation of aristolochic acid I and N-hydroxyaristolactam I in human cells.Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors.The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma.Mechanisms of base substitution mutagenesis in cancer genomes.
P2860
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P2860
Genome-wide mutational signatures of aristolochic acid and its application as a screening tool.
description
2013 nî lūn-bûn
@nan
2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Genome-wide mutational signatu ...... plication as a screening tool.
@ast
Genome-wide mutational signatu ...... plication as a screening tool.
@en
Genome-wide mutational signatu ...... plication as a screening tool.
@nl
type
label
Genome-wide mutational signatu ...... plication as a screening tool.
@ast
Genome-wide mutational signatu ...... plication as a screening tool.
@en
Genome-wide mutational signatu ...... plication as a screening tool.
@nl
prefLabel
Genome-wide mutational signatu ...... plication as a screening tool.
@ast
Genome-wide mutational signatu ...... plication as a screening tool.
@en
Genome-wide mutational signatu ...... plication as a screening tool.
@nl
P2093
P2860
P50
P1476
Genome-wide mutational signatu ...... plication as a screening tool.
@en
P2093
Bin-Kui Li
Chao-Nan Qian
Cheng-Keng Chuang
Cheng-Lung Hsu
Ching-Fang Wu
Ee Yan Siew
Hong Lee Heng
Ioana Cutcutache
John R McPherson
P2860
P304
P356
10.1126/SCITRANSLMED.3006086
P407
P50
P577
2013-08-01T00:00:00Z