Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. - sprookjes - yvandenbroek - TriplyDB

Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

http://www.wikidata.org/entity/Q34380191

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Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease Using iPS Cells toward the Understanding of Parkinson's Disease Mitochondrial targets for pharmacological intervention in human disease Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress.Applications of comparative evolution to human disease genetics Engineering enhanced protein disaggregases for neurodegenerative disease Identification of TMEM230 mutations in familial Parkinson's disease Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect Efforts to make and apply humanized yeast Yeast Augmented Network Analysis (YANA): a new systems approach to identify therapeutic targets for human genetic diseases Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.Deubiquitinating enzymes Ubp2 and Ubp15 regulate endocytosis by limiting ubiquitination and degradation of ARTs Automated multiplex genome-scale engineering in yeast Guanine nucleotide-binding protein (Gα) endocytosis by a cascade of ubiquitin binding domain proteins is required for sustained morphogenesis and proper mating in yeast.The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.Calcineurin determines toxic versus beneficial responses to α-synuclein.Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics.Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity.SOD1 oxidation and formation of soluble aggregates in yeast: relevance to sporadic ALS development.Isolating potentiated Hsp104 variants using yeast proteinopathy models Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells Yeast model identifies ENTPD6 as a potential non-obstructive azoospermia pathogenic gene.Scope and limitations of yeast as a model organism for studying human tissue-specific pathways.Covalent Tethering of Fragments For Covalent Probe Discovery Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding Process Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors.Enzyme reversal to explore the function of yeast E3 ubiquitin-ligases.A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease.NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress.Susan Lindquist: Visionary scientist and peerless mentor Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson's disease model.Impaired intracellular trafficking defines early Parkinson's disease Combating neurodegenerative disease with chemical probes and model systems.

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Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

http://www.wikidata.org/entity/Q34380191

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2013 nî lūn-bûn

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2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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Yeast reveal a "druggable" Rsp ...... synuclein toxicity in neurons.

@ast

Yeast reveal a "druggable" Rsp ...... synuclein toxicity in neurons.

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Yeast reveal a "druggable" Rsp ...... synuclein toxicity in neurons.

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label

Yeast reveal a "druggable" Rsp ...... synuclein toxicity in neurons.

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Yeast reveal a "druggable" Rsp ...... synuclein toxicity in neurons.

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Yeast reveal a "druggable" Rsp ...... synuclein toxicity in neurons.

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prefLabel

Yeast reveal a "druggable" Rsp ...... synuclein toxicity in neurons.

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Yeast reveal a "druggable" Rsp ...... synuclein toxicity in neurons.

@en

Yeast reveal a "druggable" Rsp ...... synuclein toxicity in neurons.

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Yeast reveal a "druggable" Rsp ...... -synuclein toxicity in neurons

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Daniel F Tardiff

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Nathan T Jui

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Stephen L Buchwald

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Susan Lindquist

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