Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.
about
The cell nucleus and aging: tantalizing clues and hopeful promisesLoss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in miceHuman ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severityExome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndromeProgerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblastsModel of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromesTwo faces of p53: aging and tumor suppressionLamin A-dependent nuclear defects in human agingHallmarks of progeroid syndromes: lessons from mice and reprogrammed cellsMolecular insights into the premature aging disease progeriaWhen lamins go bad: nuclear structure and diseaseAxis of ageing: telomeres, p53 and mitochondriaNuclear lamins and oxidative stress in cell proliferation and longevityThe hallmarks of agingLaminopathies and the long strange trip from basic cell biology to therapyPrelamin A farnesylation and progeroid syndromesLoss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscleEpithelial magnesium transport by TRPM6 is essential for prenatal development and adult survivalZMPSTE24 defends against influenza and other pathogenic virusesEgr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R.Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human agingInvolvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A.A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres.A common biological mechanism in cancer and Alzheimer's disease?Senescent cells: a novel therapeutic target for aging and age-related diseasesThe posttranslational processing of prelamin A and disease.DNA damage and laminsPathologies associated with the p53 response.Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status.Onset of quiescence following p53 mediated down-regulation of H2AX in normal cells.Four faces of cellular senescence.Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation.Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function.Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria.Cell autonomous and systemic factors in progeria development.The role of DNA damage in laminopathy progeroid syndromes."Laminopathies": a wide spectrum of human diseases.Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?Chromatin remodeling, DNA damage repair and aging.
P2860
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P2860
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Accelerated ageing in mice def ...... to p53 signalling activation.
@ast
Accelerated ageing in mice def ...... to p53 signalling activation.
@en
Accelerated ageing in mice def ...... to p53 signalling activation.
@nl
type
label
Accelerated ageing in mice def ...... to p53 signalling activation.
@ast
Accelerated ageing in mice def ...... to p53 signalling activation.
@en
Accelerated ageing in mice def ...... to p53 signalling activation.
@nl
prefLabel
Accelerated ageing in mice def ...... to p53 signalling activation.
@ast
Accelerated ageing in mice def ...... to p53 signalling activation.
@en
Accelerated ageing in mice def ...... to p53 signalling activation.
@nl
P2093
P2860
P50
P356
P1433
P1476
Accelerated ageing in mice def ...... d to p53 signalling activation
@en
P2093
Colin L Stewart
Francisco J Rodríguez
José A Vega
Karl Tryggvason
Luis M Sánchez
P2860
P2888
P304
P356
10.1038/NATURE04019
P407
P50
P577
2005-08-03T00:00:00Z
P5875
P6179
1048511610