Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition. - sprookjes - yvandenbroek - TriplyDB

Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.

Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.

http://www.wikidata.org/entity/Q34442342

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Oncostatic-Cytoprotective Effect of Melatonin and Other Bioactive Molecules: A Common Target in Mitochondrial Respiration Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer.Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma.Glutamate dehydrogenase is a novel prognostic marker and predicts metastases in colorectal cancer patients.Tumour-suppressive function of SIRT4 in human colorectal cancer PKM2 promotes glucose metabolism and cell growth in gliomas through a mechanism involving a let-7a/c-Myc/hnRNPA1 feedback loop.Overexpression of pyruvate kinase M2 associates with aggressive clinicopathological features and unfavorable prognosis in oral squamous cell carcinoma.miR675 upregulates long noncoding RNA H19 through activating EGR1 in human liver cancer.The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells.Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2.Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation.Polypyrimidine Tract-Binding Protein 1 promotes proliferation, migration and invasion in clear-cell renal cell carcinoma by regulating alternative splicing of PKM Double mutant P53 (N340Q/L344R) promotes hepatocarcinogenesis through upregulation of Pim1 mediated by PKM2 and LncRNA CUDR Proteomic identification of the lactate dehydrogenase A in a radioresistant prostate cancer xenograft mouse model for improving radiotherapy.Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies An important role of the hepcidin-ferroportin signaling in affecting tumor growth and metastasis.Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.Targeting the Metabolic Reprogramming That Controls Epithelial-to-Mesenchymal Transition in Aggressive Tumors.Metformin Inhibits TGF-β1-Induced Epithelial-to-Mesenchymal Transition via PKM2 Relative-mTOR/p70s6k Signaling Pathway in Cervical Carcinoma Cells.The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy.Pyruvate kinase M2 deregulation enhances the metastatic potential of tongue squamous cell carcinoma.Mammalian Target of Rapamycin (mTOR) Regulates Transforming Growth Factor-β1 (TGF-β1)-Induced Epithelial-Mesenchymal Transition via Decreased Pyruvate Kinase M2 (PKM2) Expression in Cervical Cancer Cells.PKM2 is not required for colon cancer initiated by APC loss.PKM2 in carcinogenesis and oncotherapy.Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells.Clinical Significance of Histone Demethylase NO66 in Invasive Colorectal Cancer.Multi-omics integration reveals the landscape of pro-metastasis metabolism in hepatocellular carcinoma.O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect.Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer.Down-regulation of PKM2 enhances anticancer efficiency of THP on bladder cancer.Expression of pyruvate kinase M2 in human bladder cancer and its correlation with clinical parameters and prognosis.Expression of SIP1 is strongly correlated with LDHA and shows a significantly poor outcome in gastric cancer.HK3 overexpression associated with epithelial-mesenchymal transition in colorectal cancer.Nuclear PKM2 promotes the progression of oral squamous cell carcinoma by inducing EMT and post-translationally repressing TGIF2 SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis

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Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.

http://www.wikidata.org/entity/Q34442342

description

2014 nî lūn-bûn

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2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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PNAS.1407717111

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Proceedings of the National Academy of Sciences of the United States of America

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Role of pyruvate kinase M2 in ...... thelial-mesenchymal transition

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Atsushi Hamabe

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Hideshi Ishii

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Hirofumi Yamamoto

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Hiroshi Shima

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Jun Koseki

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Kenta Tsunekuni

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Koichi Kawamoto

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Koshi Mimori

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Masamitsu Konno

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Naohiro Nishida

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Global cancer statistics

Hallmarks of Cancer: The Next Generation

Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

Understanding the Warburg effect: the metabolic requirements of cell proliferation

On the Origin of Cancer Cells

TGIF2 interacts with histone deacetylase 1 and represses transcription

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.

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15526-15531

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10.1073/PNAS.1407717111

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111

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4217454

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