Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9

Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9

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http://www.wikidata.org/entity/Q34458484

Q34458484

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Drug-induced reactivation of apoptosis abrogates HIV-1 infection In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites Short communication: high cellular iron levels are associated with increased HIV infection and replication.Hepcidin induces HIV-1 transcription inhibited by ferroportin Phenyl-1-Pyridin-2yl-ethanone-based iron chelators increase IκB-α expression, modulate CDK2 and CDK9 activities, and inhibit HIV-1 transcription 1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: application to a pilot pharmacokinetic study in rats.Select host restriction factors are associated with HIV persistence during antiretroviral therapy.Discovery of novel 5-fluoro-N(2),N(4)-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9.Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1.Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound.Inhibition of HIV-1 by curcumin A, a novel curcumin analog.HIV-1 Resistant CDK2-Knockdown Macrophage-Like Cells Generated from 293T Cell-Derived Human Induced Pluripotent Stem Cells Use of ATP analogs to inhibit HIV-1 transcription.In vitro anti-HIV-1 activity of salicylidene acylhydrazide compounds Sickle cell disease is associated with decreased HIV but higher HBV and HCV comorbidities in U.S. hospital discharge records: a cross-sectional study.Development of a sensitive HPLC method to measure in vitro permeability of E- and Z-isomeric forms of thiosemicarbazones in Caco-2 monolayers.CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90.Role of cellular iron and oxygen in the regulation of HIV-1 infection.Lentiviral Nef suppresses iron uptake in a strain specific manner through inhibition of Transferrin endocytosis.Regulation of CDK9 activity by phosphorylation and dephosphorylation.Deregulations in the cyclin-dependent kinase-9-related pathway in cancer: implications for drug discovery and development.Making a Short Story Long: Regulation of P-TEFb and HIV-1 Transcriptional Elongation in CD4+ T Lymphocytes and Macrophages.Strategies to Block HIV Transcription: Focus on Small Molecule Tat Inhibitors.Iron overload down-regulates the expression of the HIV-1 Rev cofactor eIF5A in infected T lymphocytes.Protein Phosphatase-1 -targeted Small Molecules, Iron Chelators and Curcumin Analogs as HIV-1 Antivirals.Alkaloids from the Sponge Stylissa carteri Present Prospective Scaffolds for the Inhibition of Human Immunodeficiency Virus 1 (HIV-1)Recent advances in the identification of Tat-mediated transactivation inhibitors: progressing toward a functional cure of HIV.Investigation of the salicylaldehyde thiosemicarbazone scaffold for inhibition of influenza virus PA endonuclease.Antibacterial activities of iron chelators against common nosocomial pathogens.Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03.In vitro antimicrobial activity of hydroxypyridinone hexadentate-based dendrimeric chelators alone and in combination with norfloxacin.HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription.

P2860

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P2860

Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9

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2010 nî lūn-bûn

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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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