Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.
about
Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targetingThe second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex diseaseA Review: Molecular Aberrations within Hippo Signaling in Bone and Soft-Tissue SarcomasSequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic LandscapesPotential approaches to the treatment of Ewing's sarcomaCombined experience of six independent laboratories attempting to create an Ewing sarcoma mouse modelFunctional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma.Dissecting the role of aberrant DNA methylation in human leukaemia.Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma.Loss of Ewing sarcoma EWS allele promotes tumorigenesis by inducing chromosomal instability in zebrafish.Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time.Targeting the epigenetic readers in Ewing sarcoma inhibits the oncogenic transcription factor EWS/Fli1.Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin.LOLA: enrichment analysis for genomic region sets and regulatory elements in R and Bioconductor.The role of miR-17-92 in the miRegulatory landscape of Ewing sarcoma.DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.Next steps in Ewing sarcoma (epi-)genomics.Nasopharyngeal carcinoma super-enhancer-driven ETV6 correlates with prognosis.EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma.G-quadruplex structures mark human regulatory chromatin.IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma.Activation of Wnt/β-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States.Promoter Methylation Analysis Reveals That KCNA5 Ion Channel Silencing Supports Ewing Sarcoma Cell Proliferation.ChIP-seq in studying epigenetic mechanisms of disease and promoting precision medicine: progresses and future directions.Transcriptional Addiction in Cancer.EWS-FLI1-mediated suppression of the RAS-antagonist Sprouty 1 (SPRY1) confers aggressiveness to Ewing sarcoma.A bivalent promoter contributes to stress-induced plasticity of CXCR4 in Ewing sarcomaEWS-FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway.Identification of two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma.STAT5BN642H is a driver mutation for T cell neoplasia.Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets.DNA methylation profiling opens a new phase in the search of targeted therapy against Ewing sarcoma.Precision cancer therapy is impacted by oncogene-dependent epigenome remodeling.LOLAweb: a containerized web server for interactive genomic locus overlap enrichment analysis.Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species.Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducersThe Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth
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P2860
Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.
description
2015 nî lūn-bûn
@nan
2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.
@ast
Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.
@en
Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.
@nl
type
label
Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.
@ast
Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.
@en
Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.
@nl
altLabel
Epigenome mapping reveals dist ...... ogenic fusion protein EWS-FLI1
@en
prefLabel
Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.
@ast
Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.
@en
Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.
@nl
P2860
P50
P1433
P1476
Epigenome mapping reveals dist ...... genic fusion protein EWS-FLI1.
@en
P2093
Christian Schmidl
Eleni M Tomazou
P2860
P304
P356
10.1016/J.CELREP.2015.01.042
P407
P50
P577
2015-02-19T00:00:00Z