Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers.
about
Nerve growth factor-mediated regulation of pain signalling and proposed new intervention strategies in clinical pain managementOrthopedic surgery and bone fracture pain are both significantly attenuated by sustained blockade of nerve growth factor.Mechanisms of nerve growth factor signaling in bone nociceptors and in an animal model of inflammatory bone pain.Emerging therapies in metastatic bone pain.The neurobiology of skeletal painAdministration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain.The majority of myelinated and unmyelinated sensory nerve fibers that innervate bone express the tropomyosin receptor kinase A.Antagonism of nerve growth factor-TrkA signaling and the relief of painModeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer.Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis.Pain, Genes, and Function in the Post-Hip Fracture PeriodPerineural invasion and associated pain in pancreatic cancer.Cdk5: An Emerging Kinase in Pain SignalingAnti-nerve growth factor therapy increases spontaneous day/night activity in mice with orthopedic surgery-induced pain.Challenges to develop novel anti-inflammatory and analgesic drugs.ISSLS PRIZE IN BASIC SCIENCE 2017: Intervertebral disc/bone marrow cross-talk with Modic changes.Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis.Analgesia via blockade of NGF/TrkA signaling does not influence fracture healing in mice.Molecular Mechanisms That Contribute to Bone Marrow PainAnalysis of the mechanism by which nerve growth factor promotes callus formation in mice with tibial fracture.Immunohistochemical localization of nerve growth factor, tropomyosin receptor kinase A, and p75 in the bone and articular cartilage of the mouse femur.The Trk family of neurotrophin receptors is downregulated in the lumbar spines of rats with congenital kyphoscoliosis.Anti-nerve growth factor therapy attenuates cutaneous hypersensitivity and musculoskeletal discomfort in mice with osteoporosis.
P2860
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P2860
Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Sustained blockade of neurotro ...... and sympathetic nerve fibers.
@ast
Sustained blockade of neurotro ...... and sympathetic nerve fibers.
@en
Sustained blockade of neurotro ...... and sympathetic nerve fibers.
@nl
type
label
Sustained blockade of neurotro ...... and sympathetic nerve fibers.
@ast
Sustained blockade of neurotro ...... and sympathetic nerve fibers.
@en
Sustained blockade of neurotro ...... and sympathetic nerve fibers.
@nl
prefLabel
Sustained blockade of neurotro ...... and sympathetic nerve fibers.
@ast
Sustained blockade of neurotro ...... and sympathetic nerve fibers.
@en
Sustained blockade of neurotro ...... and sympathetic nerve fibers.
@nl
P2093
P2860
P1433
P1476
Sustained blockade of neurotro ...... and sympathetic nerve fibers.
@en
P2093
Aaron P Bloom
David Trollinger
James Winkler
Joseph R Ghilardi
Juan M Jimenez-Andrade
Karyn S Bouhana
Katie T Freeman
Michael A Kuskowski
Patrice Lee
Patrick W Mantyh
P2860
P304
P356
10.1016/J.BONE.2010.09.019
P577
2010-09-18T00:00:00Z