Structural characterization of human heparanase reveals insights into substrate recognition. - sprookjes - yvandenbroek - TriplyDB

Structural characterization of human heparanase reveals insights into substrate recognition.

Structural characterization of human heparanase reveals insights into substrate recognition.

http://www.wikidata.org/entity/Q34501966

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Recent Insights into Cell Surface Heparan Sulphate Proteoglycans and Cancer Base-resolution profiling of active DNA demethylation using MAB-seq and caMAB-seq Mechanisms of heparanase inhibitors in cancer therapy.Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells.Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of λ-Carrageenan Derivative as a Potent Anti Angiogenic Agent Activity-based probes for functional interrogation of retaining β-glucuronidases.Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity HMGB1 exacerbates bronchiolitis obliterans syndrome via RAGE/NF-κB/HPSE signaling to enhance latent TGF-β release from ECM.Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics.Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases.Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy.Methyltransferase-Directed Labeling of Biomolecules and its Applications.Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease.Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase.Heparanase and cancer progression: New directions, new promises.Emerging Roles of Heparanase in Viral Pathogenesis.Heparanase: From basic research to therapeutic applications in cancer and inflammation.Opposing Functions of Heparanase-1 and Heparanase-2 in Cancer Progression.Glycosidase Inhibition by Multivalent Presentation of Heparan Sulfate Saccharides on Bottlebrush Polymers.Cloning and bacterial expression systems for recombinant human heparanase production: Substrate specificity investigation by docking of a putative heparanase substrate.Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine.Patient derived xenografts (PDX) predict an effective heparanase-based therapy for lung cancer.Investigating Glycol-Split-Heparin-Derived Inhibitors of Heparanase: A Study of Synthetic Trisaccharides Glycosaminoglycan-Protein Interactions by Nuclear Magnetic Resonance (NMR) Spectroscopy

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P2860

Structural characterization of human heparanase reveals insights into substrate recognition.

http://www.wikidata.org/entity/Q34501966

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2015 nî lūn-bûn

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2015 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2015年の論文

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2015年論文

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Nature Structural & Molecular Biology

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Structural characterization of ...... hts into substrate recognition

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Andrzej M Brzozowski

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Cristina M Viola

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P2860

Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis

Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization

Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence

N.m.r. and molecular-modelling studies of the solution conformation of heparin

MolProbity: all-atom structure validation for macromolecular crystallography

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

Structural and Biochemical Characterization of Glycoside Hydrolase Family 79 β-Glucuronidase from Acidobacterium capsulatum

Functional and structural characterization of a heparanase

Heparin structure and interactions with basic fibroblast growth factor

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10.1038/NSMB.3136

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12

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22

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26575439

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alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc-(1->4)-beta-D-GlcA-O-pNP

alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-O-pNP

beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNS(6S)-(1->4)-beta-D-GlcA-O-pNP

beta-D-DeltaHexA(2S)-(1->4)-alpha-D-GlcNS(6S)-(1->4)-alpha-L-IdoA-(1->4)-alpha-D-GlcNS(6S)

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5008439

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