Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfide - sprookjes - yvandenbroek - TriplyDB

Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfide

Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfide

http://www.wikidata.org/entity/Q34503391

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Hydrogen sulfide chemical biology: pathophysiological roles and detection Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapies Therapeutic potential of PDE modulation in treating heart disease Phosphodiesterases and cardiac cGMP: evolving roles and controversies Cytoprotection by the modulation of mitochondrial electron transport chain: the emerging role of mitochondrial STAT3 Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats The Effect of Sorafenib, Tadalafil and Macitentan Treatments on Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities Effects of sildenafil and/or muscle derived stem cells on myocardial infarction.Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling.Aortic valve: mechanical environment and mechanobiology.mTORC2 phosphorylation of Akt1: a possible mechanism for hydrogen sulfide-induced cardioprotection.PDE5 inhibitor efficacy is estrogen dependent in female heart disease.Induction of microRNA-21 with exogenous hydrogen sulfide attenuates myocardial ischemic and inflammatory injury in mice Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect.Chronic treatment with long acting phosphodiesterase-5 inhibitor tadalafil alters proteomic changes associated with cytoskeletal rearrangement and redox regulation in Type 2 diabetic hearts.cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.Targeting cyclic nucleotide phosphodiesterase in the heart: therapeutic implications.Cyclic guanosine monophosphate signaling and phosphodiesterase-5 inhibitors in cardioprotection.Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice Protein kinase G1 α overexpression increases stem cell survival and cardiac function after myocardial infarction.Mitigation of the progression of heart failure with sildenafil involves inhibition of RhoA/Rho-kinase pathway Gas what: NO is not the only answer to sexual function.Altered oxido-reductive state in the diabetic heart: loss of cardioprotection due to protein disulfide isomerase Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cells.Emerging new uses of phosphodiesterase-5 inhibitors in cardiovascular diseases.Tadalafil Integrates Nitric Oxide-Hydrogen Sulfide Signaling to Inhibit High Glucose-induced Matrix Protein Synthesis in Podocytes PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer Cinaciguat, a novel activator of soluble guanylate cyclase, protects against ischemia/reperfusion injury: role of hydrogen sulfide.Adenoviral short hairpin RNA therapy targeting phosphodiesterase 5a relieves cardiac remodeling and dysfunction following myocardial infarction Shared signaling pathways among gasotransmitters.Analysis of erectile responses to H2S donors in the anesthetized rat.cGMP-Phosphodiesterase Inhibition Prevents Hypoxia-Induced Cell Death Activation in Porcine Retinal Explants Hydrogen sulfide and PKG in ischemia-reperfusion injury: sources, signaling, accelerators and brakes.SIRTUIN 1 ACTIVATOR SRT1720 PROTECTS AGAINST ORGAN INJURY INDUCED BY INTESTINAL ISCHEMIA-REPERFUSION Thiosulfate Mediates Cytoprotective Effects of Hydrogen Sulfide Against Neuronal Ischemia.Oncostatin M-induced cardiomyocyte dedifferentiation regulates the progression of diabetic cardiomyopathy through B-Raf/Mek/Erk signaling pathway.Beetroot juice reduces infarct size and improves cardiac function following ischemia-reperfusion injury: Possible involvement of endogenous H2S Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure Hydrogen sulfide and erectile function: a novel therapeutic target.Role of hydrogen sulfide in the physiology of penile erection

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Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfide

http://www.wikidata.org/entity/Q34503391

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2009 nî lūn-bûn

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2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Phosphodiesterase-5 inhibitor, ...... generation of hydrogen sulfide

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Phosphodiesterase-5 inhibitor, ...... generation of hydrogen sulfide

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Amit Varma

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Antonio Abbate

http://www.w3.org/2001/XMLSchema#string

Fadi N Salloum

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Nicholas N Hoke

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Rakesh C Kukreja

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Ramzi A Ockaili

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Stefano Toldo

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Vinh Q Chau

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P2860

H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase

Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression

Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function

Rising behind NO: cGMP-dependent protein kinases.

Invited review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression.

Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo.

Efficacy and tolerability of tadalafil, a novel phosphodiesterase 5 inhibitor, in treatment of erectile dysfunction.

Toxicology of hydrogen sulfide.

The ubiquitous role of nitric oxide in cardioprotection.

Free radical biology and medicine: it's a gas, man!

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S31-6

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scholarly article

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10.1161/CIRCULATIONAHA.108.843979

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11 Suppl

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2009-09-01T00:00:00Z

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4230451

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