Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes
about
Treatment of Erdheim-Chester disease with cladribine: a rational approachApplication of population pharmacokinetics to cladribine.Pentostatin in chronic lymphocytic leukemiaDeoxyadenosine triphosphate as a mediator of deoxyguanosine toxicity in cultured T lymphoblastsInduction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome cNucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathwayCladribine Exposure Results in a Sustained Modulation of the Cytokine Response in Human Peripheral Blood Mononuclear CellsIntermittent 2-hour-infusion of cladribine as first-line therapy or in first relapse of progressive advanced low-grade and mantle cell lymphomas.Cladribine in the treatment of chronic lymphocytic leukemia.A phase I and pharmacokinetics study of 2-chlorodeoxyadenosine in patients with solid tumors.2'-Chlorodeoxyadenosine: evaluation of a novel predominantly lymphocyte selective agent in lymphoid malignancies.Cladribine in the treatment of advanced relapsed or refractory low and intermediate grade non-Hodgkin's lymphoma.Es nucleoside transporter content of acute leukemia cells: role in cell sensitivity to cytarabine (araC).Polyadenylation inhibition by the triphosphates of deoxyadenosine analogues.Nucleotide pool imbalance and adenosine deaminase deficiency induce alterations of N-region insertions during V(D)J recombination.Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death.Membrane phenotype and response to deoxycoformycin in mature T cell malignanciesTherapeutic potential of purine analogue combinations in the treatment of lymphoid malignancies.Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy.Chronic cladribine administration increases amyloid beta peptide generation and plaque burden in mice.Cancer chemotherapy: new strategies for success.Role of nicotinamide adenine dinucleotide and adenosine triphosphate in glucocorticoid-induced cytotoxicity in susceptible lymphoid cells.Cladribine: not just another purine analogue?The cladribine conundrum: deciphering the drug's mechanism of action.Emerging therapies for treatment of multiple sclerosisHuman autoantibodies to poly(adenosine diphosphate-ribose) polymeraseDeficiency of adenosine deaminase in the wasted mouseMechanisms of apoptosis induction by nucleoside analogs.Pharmacological basis for cladribine resistance.Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.Cell death of bioenergetically compromised and transcriptionally challenged CLL lymphocytes by chlorinated ATPLymphocyte dysfunction after DNA damage by toxic oxygen species. A model of immunodeficiency.Biochemical pathways of apoptosis: nicotinamide adenine dinucleotide-deficient cells are resistant to tumor necrosis factor or ultraviolet light activation of the 24-kD apoptotic protease and DNA fragmentationThe binding site of human adenosine deaminase for CD26/Dipeptidyl peptidase IV: the Arg142Gln mutation impairs binding to cd26 but does not cause immune deficiency.Pentostatin and purine analogs for indolent lymphoid malignancies.Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients.2-CdA in the treatment of hairy cell leukemia: a review of long-term follow-up.Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosineCladribine in indolent non-Hodgkin's lymphoma.Insights into thymic purine metabolism and adenosine deaminase deficiency revealed by transgenic mice overexpressing ecto-5'-nucleotidase (CD73).
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P2860
Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes
description
1985 nî lūn-bûn
@nan
1985 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1985 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
name
Mechanism of deoxyadenosine an ...... nondividing human lymphocytes
@ast
Mechanism of deoxyadenosine an ...... nondividing human lymphocytes
@en
Mechanism of deoxyadenosine an ...... nondividing human lymphocytes
@nl
type
label
Mechanism of deoxyadenosine an ...... nondividing human lymphocytes
@ast
Mechanism of deoxyadenosine an ...... nondividing human lymphocytes
@en
Mechanism of deoxyadenosine an ...... nondividing human lymphocytes
@nl
prefLabel
Mechanism of deoxyadenosine an ...... nondividing human lymphocytes
@ast
Mechanism of deoxyadenosine an ...... nondividing human lymphocytes
@en
Mechanism of deoxyadenosine an ...... nondividing human lymphocytes
@nl
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P356
P1476
Mechanism of deoxyadenosine an ...... nondividing human lymphocytes
@en
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P2860
P304
P356
10.1172/JCI111710
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P577
1985-02-01T00:00:00Z