Independent modulation of von Willebrand factor and fibrinogen binding to the platelet membrane glycoprotein IIb/IIIa complex as demonstrated by monoclonal antibody.
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Human platelets recognize a novel surface protein, PadA, on Streptococcus gordonii through a unique interaction involving fibrinogen receptor GPIIbIIIa.Distinct abnormalities in the interaction of purified types IIA and IIB von Willebrand factor with the two platelet binding sites, glycoprotein complexes Ib-IX and IIb-IIIaAgkistrodon piscivorus piscivorus platelet aggregation inhibitor: a potent inhibitor of platelet activation.Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor.Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb-IIIa complex at high shear rate.von Willebrand factor interaction with the glycoprotein IIb/IIa complex. Its role in platelet function as demonstrated in patients with congenital afibrinogenemia.Type IIB von Willebrand factor with normal sialic acid content induces platelet aggregation in the absence of ristocetin. Role of platelet activation, fibrinogen, and two distinct membrane receptorsEffects of monoclonal antibodies against the platelet glycoprotein IIb/IIIa complex on thrombosis and hemostasis in the baboon.Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogenAffinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptorDistinct mechanisms of platelet aggregation as a consequence of different shearing flow conditions.Inhibition of platelet function with synthetic peptides designed to be high-affinity antagonists of fibrinogen binding to platelets.Nonsense mutation in the glycoprotein Ib alpha coding sequence associated with Bernard-Soulier syndromeRegulation of long-term repopulating hematopoietic stem cells by EPCR/PAR1 signalingInhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin alpha 9beta 1 with VCAM-1, tenascin-C, and osteopontin.The activation state of the integrin alpha IIb beta 3 affects outside-in signals leading to cell spreading and focal adhesion kinase phosphorylation.Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to platelets.Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model.
P2860
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P2860
Independent modulation of von Willebrand factor and fibrinogen binding to the platelet membrane glycoprotein IIb/IIIa complex as demonstrated by monoclonal antibody.
description
1985 nî lūn-bûn
@nan
1985 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1985 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
name
Independent modulation of von ...... trated by monoclonal antibody.
@ast
Independent modulation of von ...... trated by monoclonal antibody.
@en
Independent modulation of von ...... trated by monoclonal antibody.
@nl
type
label
Independent modulation of von ...... trated by monoclonal antibody.
@ast
Independent modulation of von ...... trated by monoclonal antibody.
@en
Independent modulation of von ...... trated by monoclonal antibody.
@nl
prefLabel
Independent modulation of von ...... trated by monoclonal antibody.
@ast
Independent modulation of von ...... trated by monoclonal antibody.
@en
Independent modulation of von ...... trated by monoclonal antibody.
@nl
P2093
P2860
P356
P1476
Independent modulation of von ...... trated by monoclonal antibody.
@en
P2093
J R Roberts
T J Kunicki
T S Zimmerman
V T Lombardo
Z M Ruggeri
P2860
P304
P356
10.1172/JCI112193
P407
P577
1985-11-01T00:00:00Z