DNA mismatch-specific targeting and hypersensitivity of mismatch-repair-deficient cells to bulky rhodium(III) intercalators.
about
The path for metal complexes to a DNA targetInsights into finding a mismatch through the structure of a mispaired DNA bound by a rhodium intercalatorA Bulky Rhodium Complex Bound to an Adenosine-Adenosine DNA Mismatch: General Architecture of the Metalloinsertion Binding ModeDouble threading through DNA: NMR structural study of a bis-naphthalene macrocycle bound to a thymine-thymine mismatchLuminescent properties of ruthenium(II) complexes with sterically expansive ligands bound to DNA defects.An unusual ligand coordination gives rise to a new family of rhodium metalloinsertors with improved selectivity and potency.A monofunctional platinum complex coordinated to a rhodium metalloinsertor selectively binds mismatched DNA in the minor groove.Targeting DNA Mismatches with Rhodium Metalloinsertors.An inducible, isogenic cancer cell line system for targeting the state of mismatch repair deficiency.Targeting karyotypic complexity and chromosomal instability of cancer cells.Selective recognition of pyrimidine-pyrimidine DNA mismatches by distance-constrained macrocyclic bis-intercalatorsMetallo-intercalators and metallo-insertorsCell-selective biological activity of rhodium metalloinsertors correlates with subcellular localizationMechanism of cellular uptake of a ruthenium polypyridyl complex.Binding of Ru(bpy)2(eilatin)2+ to matched and mismatched DNA.Insertion of a bulky rhodium complex into a DNA cytosine-cytosine mismatch: an NMR solution study.DNA base mismatch detection with bulky rhodium intercalators: synthesis and applications.Towards artificial metallonucleases for gene therapy: recent advances and new perspectives.Finding needles in a basestack: recognition of mismatched base pairs in DNA by small molecules.DNA strand cleavage near a CC mismatch directed by a metalloinsertorDNA mismatch binding and antiproliferative activity of rhodium metalloinsertors.Selective cytotoxicity of rhodium metalloinsertors in mismatch repair-deficient cells.Selective tumor cell death induced by irradiated riboflavin through recognizing DNA G-T mismatch.Fluorescein redirects a ruthenium-octaarginine conjugate to the nucleusBiological effects of simple changes in functionality on rhodium metalloinsertors.Methods to explore cellular uptake of ruthenium complexesTargeting abasic sites and single base bulges in DNA with metalloinsertors.Targeted Chemotherapy with Metal Complexes.Macrocyclic DNA-mismatch-binding ligands: structural determinants of selectivity.Rhodium metalloinsertor binding generates a lesion with selective cytotoxicity for mismatch repair-deficient cells.A Rhodium-Cyanine Fluorescent Probe: Detection and Signaling of Mismatches in DNA.A Family of Rhodium Complexes with Selective Toxicity toward Mismatch Repair-Deficient Cancers.Bis(o-methylserotonin)-containing iridium(III) and ruthenium(II) complexes as new cellular imaging dyes: synthesis, applications, and photophysical and computational studiesGold(iii) complexes inhibit growth of cisplatin-resistant ovarian cancer in association with upregulation of proapoptotic PMS2 gene
P2860
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P2860
DNA mismatch-specific targeting and hypersensitivity of mismatch-repair-deficient cells to bulky rhodium(III) intercalators.
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
DNA mismatch-specific targetin ...... ficient cells to bulky rhodium
@nl
DNA mismatch-specific targetin ...... ky rhodium(III) intercalators.
@ast
DNA mismatch-specific targetin ...... ky rhodium(III) intercalators.
@en
type
label
DNA mismatch-specific targetin ...... ficient cells to bulky rhodium
@nl
DNA mismatch-specific targetin ...... ky rhodium(III) intercalators.
@ast
DNA mismatch-specific targetin ...... ky rhodium(III) intercalators.
@en
prefLabel
DNA mismatch-specific targetin ...... ficient cells to bulky rhodium
@nl
DNA mismatch-specific targetin ...... ky rhodium(III) intercalators.
@ast
DNA mismatch-specific targetin ...... ky rhodium(III) intercalators.
@en
P2093
P2860
P356
P1476
DNA mismatch-specific targetin ...... ky rhodium(III) intercalators.
@en
P2093
Ilan R Kirsch
Jacqueline K Barton
Jonathan R Hart
Oleg Glebov
Russell J Ernst
P2860
P304
15359-15363
P356
10.1073/PNAS.0607576103
P407
P577
2006-10-09T00:00:00Z