Engineering of a functional human NADH-dependent cytochrome P450 system
about
Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductaseNADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transferInvolvement of the pyrophosphate and the 2'-phosphate binding regions of ferredoxin-NADP+ reductase in coenzyme specificityThe crystal structure of the FAD/NADPH-binding domain of flavocytochrome P450 BM3Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamilyHuman NADPH-P450 oxidoreductase modulates the level of cytochrome P450 CYP2D6 holoprotein via haem oxygenase-dependent and -independent pathwaysBiochemical comparison of Anopheles gambiae and human NADPH P450 reductases reveals different 2'-5'-ADP and FMN binding traitsCharacterization of the mechanism of cytochrome P450 reductase-cytochrome P450-mediated nitric oxide and nitrosothiol generation from organic nitratesEngineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediationModulation of the enzymatic efficiency of ferredoxin-NADP(H) reductase by the amino acid volume around the catalytic site.The P450 oxidoreductase, RedA, controls development beyond the mound stage in Dictyostelium discoideum.A conserved flavin-shielding residue regulates NO synthase electron transfer and nicotinamide coenzyme specificityNADPH-cytochrome P450 oxidoreductase from the mosquito Anopheles minimus: kinetic studies and the influence of Leu86 and Leu219 on cofactor binding and protein stabilityP450(BM3) (CYP102A1): connecting the dots.High-resolution studies of hydride transfer in the ferredoxin:NADP+ reductase superfamily.Modeling of Anopheles minimus Mosquito NADPH-cytochrome P450 oxidoreductase (CYPOR) and mutagenesis analysis.Co-expression of active human cytochrome P450 1A2 and cytochrome P450 reductase on the cell surface of Escherichia coli.Modification of the nucleotide cofactor-binding site of cytochrome P-450 reductase to enhance turnover with NADH in Vivo.Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues.The FAD-shielding residue Phe1395 regulates neuronal nitric-oxide synthase catalysis by controlling NADP+ affinity and a conformational equilibrium within the flavoprotein domain.Thermodynamic and kinetic analysis of the isolated FAD domain of rat neuronal nitric oxide synthase altered in the region of the FAD shielding residue Phe1395.Switching pyridine nucleotide specificity in P450 BM3: mechanistic analysis of the W1046H and W1046A enzymes.Kinetic analysis of cytochrome P450 reductase from Artemisia annua reveals accelerated rates of NADH-dependent flavin reduction.Structural and Kinetic Studies of Asp632 Mutants and Fully Reduced NADPH-Cytochrome P450 Oxidoreductase Define the Role of Asp632 Loop Dynamics in the Control of NADPH Binding and Hydride Transfer.Protein Engineering for Nicotinamide Coenzyme Specificity in Oxidoreductases: Attempts and Challenges.Probing the NADH- and Methyl Red-binding site of a FMN-dependent azoreductase (AzoA) from Enterococcus faecalis.Aromatic substitution of the FAD-shielding tryptophan reveals its differential role in regulating electron flux in methionine synthase reductase and cytochrome P450 reductase.
P2860
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P2860
Engineering of a functional human NADH-dependent cytochrome P450 system
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Engineering of a functional human NADH-dependent cytochrome P450 system
@ast
Engineering of a functional human NADH-dependent cytochrome P450 system
@en
Engineering of a functional human NADH-dependent cytochrome P450 system
@nl
type
label
Engineering of a functional human NADH-dependent cytochrome P450 system
@ast
Engineering of a functional human NADH-dependent cytochrome P450 system
@en
Engineering of a functional human NADH-dependent cytochrome P450 system
@nl
prefLabel
Engineering of a functional human NADH-dependent cytochrome P450 system
@ast
Engineering of a functional human NADH-dependent cytochrome P450 system
@en
Engineering of a functional human NADH-dependent cytochrome P450 system
@nl
P2093
P2860
P356
P1476
Engineering of a functional human NADH-dependent cytochrome P450 system
@en
P2093
P2860
P356
10.1073/PNAS.98.1.81
P407
P577
2001-01-01T00:00:00Z