The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation.
about
p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacityGenome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2pEvidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activityPhosphorylation of initiation factor eIF2 in response to stress conditions is mediated by acidic ribosomal P1/P2 proteins in Saccharomyces cerevisiae.IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activationEnhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cellsTransfer RNA and human diseasetRNAs as regulators of biological processesGcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress.tRNA-mediated transcription antitermination in vitro: codon-anticodon pairing independent of the ribosomeThe GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2.Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses.Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae.Differential activation of eIF2 kinases in response to cellular stresses in Schizosaccharomyces pombe.GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment.Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo.Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR.Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2.Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae.Rapid and reversible nuclear accumulation of cytoplasmic tRNA in response to nutrient availability.Novel membrane-bound eIF2alpha kinase in the flagellar pocket of Trypanosoma bruceiSolution structure of the RWD domain of the mouse GCN2 proteinMechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae.A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2.Stress puts TIA on TOP.Activation of Gcn2 in response to different stresses.General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae.Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner.Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2.Genetic code ambiguity. Cell viability related to the severity of editing defects in mutant tRNA synthetases.Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions.GCN2- and eIF2α-phosphorylation-independent, but ATF4-dependent, induction of CARE-containing genes in methionine-deficient cells.Functional characterization of Drosophila melanogaster PERK eukaryotic initiation factor 2alpha (eIF2alpha) kinase.A low-protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21).Regulation of Sensing, Transportation, and Catabolism of Nitrogen Sources in Saccharomyces cerevisiae.ATF4 Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming.Effects of single amino acid deficiency on mRNA translation are markedly different for methionine versus leucine.
P2860
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P2860
The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The tRNA-binding moiety in GCN ...... binding and kinase activation.
@ast
The tRNA-binding moiety in GCN ...... binding and kinase activation.
@en
The tRNA-binding moiety in GCN ...... binding and kinase activation.
@nl
type
label
The tRNA-binding moiety in GCN ...... binding and kinase activation.
@ast
The tRNA-binding moiety in GCN ...... binding and kinase activation.
@en
The tRNA-binding moiety in GCN ...... binding and kinase activation.
@nl
prefLabel
The tRNA-binding moiety in GCN ...... binding and kinase activation.
@ast
The tRNA-binding moiety in GCN ...... binding and kinase activation.
@en
The tRNA-binding moiety in GCN ...... binding and kinase activation.
@nl
P2093
P2860
P356
P1433
P1476
The tRNA-binding moiety in GCN ...... binding and kinase activation.
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/20.6.1425
P407
P577
2001-03-01T00:00:00Z