The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes. - sprookjes - yvandenbroek - TriplyDB

The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.

The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.

http://www.wikidata.org/entity/Q34618662

about

Adjuvants: Classification, Modus Operandi, and Licensing Ontogeny of early life immunity Structure-Based Design of Novel Human Toll-like Receptor 8 Agonists Neonatal Vaccination: Challenges and Intervention Strategies An alphavirus-based adjuvant enhances serum and mucosal antibodies, T cells, and protective immunity to influenza virus in neonatal mice Targeting regulatory T cells to improve vaccine immunogenicity in early life.Soluble mediators regulating immunity in early life Decreased pattern recognition receptor signaling, interferon-signature, and bactericidal/permeability-increasing protein gene expression in cord blood of term low birth weight human newborns.Flagellin as carrier and adjuvant in cocaine vaccine development.Ready to benefit from training: heterologous effects of early life immunization.The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.Arterial Catheterization and Infection: Toll-like Receptors in Defense against Microorganisms and Therapeutic Implications Naturally Occurring Subclinical Endotoxemia in Humans Alters Adaptive and Innate Immune Functions through Reduced MAPK and Increased STAT1 Phosphorylation In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant.The host STING pathway at the interface of cancer and immunity Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures.A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity.TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth.Vaccines against respiratory viral pathogens for use in neonates: opportunities and challenges.Potential approaches for more successful dendritic cell-based immunotherapy.Impact of Early-Life Exposures to Infections, Antibiotics, and Vaccines on Perinatal and Long-term Health and Disease.Strategies for designing synthetic immune agonists.Innate immune mediators in cancer: between defense and resistance.Innate immune signaling and regulation in cancer immunotherapy.Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses.Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns.Prospective study of the innate cellular immune response in low vaccine responder children.Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization.α-Galactosylceramide stimulates splenic lymphocyte proliferation in vitro and increases antibody production in vivo in late neonatal-age mice.Exquisite selectivity for human toll-like receptor 8 in substituted furo[2,3-c]quinolines.Identification of single nucleotide polymorphisms in hematopoietic cell transplant patients affecting early recognition of, and response to, endotoxin.Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization.Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn.Overcoming the Neonatal Limitations of Inducing Germinal Centers through Liposome-Based Adjuvants Including C-Type Lectin Agonists Trehalose Dibehenate or Curdlan.

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The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.

http://www.wikidata.org/entity/Q34618662

description

2013 nî lūn-bûn

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2013 թուականի Մարտին հրատարակուած գիտական յօդուած

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2013 թվականի մարտին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

The ultra-potent and selective ...... newborn and adult leukocytes.

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The ultra-potent and selective ...... newborn and adult leukocytes.

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The ultra-potent and selective ...... newborn and adult leukocytes.

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The ultra-potent and selective ...... newborn and adult leukocytes.

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The ultra-potent and selective ...... newborn and adult leukocytes.

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The ultra-potent and selective ...... newborn and adult leukocytes.

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The ultra-potent and selective ...... newborn and adult leukocytes.

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The ultra-potent and selective ...... newborn and adult leukocytes.

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The ultra-potent and selective ...... newborn and adult leukocytes.

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The ultra-potent and selective ...... newborn and adult leukocytes.

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Christine D Palmer

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David J Dowling

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Gregory N Dietsch

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Maura-Ann H Matthews

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Ofer Levy

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Zhen Tan

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P2860

Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

Immune response to vaccine adjuvants during the first year of life

A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants

Comparative analysis of species-specific ligand recognition in Toll-like receptor 8 signaling: a hypothesis

Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants

Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta

Immunoprofiling toll-like receptor ligands: Comparison of immunostimulatory and proinflammatory profiles in ex vivo human blood models.

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