Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia. - sprookjes - yvandenbroek - TriplyDB

Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia.

Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia.

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The Use of Stem Cells to Model Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: From Basic Research to Regenerative Medicine Frontotemporal Lobar Degeneration and MicroRNAs Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation The Activity-Induced Long Non-Coding RNA Meg3 Modulates AMPA Receptor Surface Expression in Primary Cortical Neurons.Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia Function and evolution of microRNAs in eusocial Hymenoptera.Probing disorders of the nervous system using reprogramming approaches.Distinct cognitive effects and underlying transcriptome changes upon inhibition of individual miRNAs in hippocampal neurons.FTD/ALS-associated poly(GR) protein impairs the Notch pathway and is recruited by poly(GA) into cytoplasmic inclusions Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology.Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS.TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III.MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity.α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice.miR-124, -128, and -137 Orchestrate Neural Differentiation by Acting on Overlapping Gene Sets Containing a Highly Connected Transcription Factor Network.GluA4 Dependent Plasticity Mechanisms Contribute to Developmental Synchronization of the CA3-CA1 Circuitry in the Hippocampus.Modeling the C9ORF72 repeat expansion mutation using human induced pluripotent stem cells.The role of CHMP2BIntron5 in autophagy and frontotemporal dementia.ALS and FTD: an epigenetic perspective.Review: Induced pluripotent stem cell models of frontotemporal dementia.Validation of microRNAs in Cerebrospinal Fluid as Biomarkers for Different Forms of Dementia in a Multicenter Study.A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia.Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test.Anti-AMPA GluA3 antibodies in Frontotemporal dementia: a new molecular target.Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma.Cocaine-mediated downregulation of microglial miR-124 expression involves promoter DNA methylation.Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference.Neurotransmitter deficits from frontotemporal lobar degeneration.C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.Association of social defeat stress-induced anhedonia-like symptoms with mGluR1-dependent decrease in membrane-bound AMPA-GluR1 in the mouse ventral midbrain.Dysregulated molecular pathways in amyotrophic lateral sclerosis-frontotemporal dementia spectrum disorder.Dysregulation of Cortical Neuron DNA Methylation Profile in Autism Spectrum Disorder.Identification of MicroRNA-124-3p as a Putative Epigenetic Signature of Major Depressive Disorder.Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability.Cocaine-Mediated Downregulation of miR-124 Activates Microglia by Targeting KLF4 and TLR4 Signaling.Synaptic dysfunction and altered excitability in C9ORF72 ALS/FTD.Epigenetic Mechanisms of Gene Regulation in Amyotrophic Lateral Sclerosis.miR-124 Contributes to the functional maturity of microglia.Molecular Genetics of Frontotemporal Dementia Elucidated by Drosophila Models-Defects in Endosomal⁻Lysosomal Pathway.

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Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia.

http://www.wikidata.org/entity/Q34642142

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2014 nî lūn-bûn

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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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Alterations in microRNA-124 an ...... ts in frontotemporal dementia.

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Alterations in microRNA-124 an ...... ts in frontotemporal dementia.

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Alterations in microRNA-124 an ...... ts in frontotemporal dementia.

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Alterations in microRNA-124 an ...... ts in frontotemporal dementia.

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Alterations in microRNA-124 an ...... ts in frontotemporal dementia.

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Alterations in microRNA-124 an ...... ts in frontotemporal dementia.

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Alterations in microRNA-124 an ...... ts in frontotemporal dementia.

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Alterations in microRNA-124 an ...... ts in frontotemporal dementia.

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Danqiong Sun

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Dennis W Dickson

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Fen-Biao Gao

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Hongru Zhou

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Hongyu Ruan

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Jamie M Verheyden

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Jian Jiao

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Kelleen Lynch

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Leonard Petrucelli

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Sandra Almeida

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Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

Membrane budding and scission by the ESCRT machinery: it's all in the neck

Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis

The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration

Neuropathological alterations in Alzheimer disease

The functions of animal microRNAs

ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration

Structure-stability-function relationships of dendritic spines

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

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10.1038/NM.3717

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