Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.
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Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA functionCurrent Insights into Molecular Mechanisms of Alzheimer Disease and Their Implications for Therapeutic ApproachesLRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's diseaseAmyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's diseaseAlzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasisLithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's diseaseAllele-specific RNAi mitigates phenotypic progression in a transgenic model of Alzheimer's disease.Alzheimer's Disease in Down Syndrome.Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in DrosophilaA nuclear factor-binding domain in the 5'-untranslated region of the amyloid precursor protein promoter: implications for the regulation of gene expression.Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-betaExcess betaCTF, not Abeta: the culprit in Alzheimer-related endocytic dysfunction.Recent insights into the molecular genetics of dementiaCurrent status on Alzheimer disease molecular genetics: from past, to present, to future.MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons.Understanding microRNAs in neurodegeneration.hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodiesCopy number variation in human health, disease, and evolution.The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice.Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice.MicroRNA-153 physiologically inhibits expression of amyloid-β precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients.Using BAC transgenesis in zebrafish to identify regulatory sequences of the amyloid precursor protein gene in humans.Post-transcriptional regulation of amyloid precursor protein by microRNAs and RNA binding proteins.Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model.Whole genome sequence analysis suggests intratumoral heterogeneity in dissemination of breast cancer to lymph nodesCancer and neurodegenerative disorders: pathogenic convergence through microRNA regulation.Genetics of Vascular Dementia.Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies.Aneuploid proliferation defects in yeast are not driven by copy number changes of a few dosage-sensitive genes.Replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence creates murine model of major depressive disorderMonoallelic expression of the human FOXP2 speech gene.Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3β (GSK3β) activity: novel mechanism for Pin1 to protect against Alzheimer disease.Neuroinflammatory Cytokines-The Common Thread in Alzheimer's PathogenesisRole of common and rare APP DNA sequence variants in Alzheimer diseaseTargeting protein aggregation for the treatment of degenerative diseasesAPOE and AβPP gene variation in cortical and cerebrovascular amyloid-β pathology and Alzheimer's disease: a population-based analysisMutation in the 3'untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy.Down syndrome and Alzheimer's disease: Common pathways, common goals.Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology.Molecular genetics of Alzheimer's disease: an update.
P2860
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P2860
Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.
description
2006 nî lūn-bûn
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2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Promoter mutations that increa ...... ciated with Alzheimer disease.
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Promoter mutations that increa ...... ciated with Alzheimer disease.
@en
Promoter mutations that increa ...... ciated with Alzheimer disease.
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type
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Promoter mutations that increa ...... ciated with Alzheimer disease.
@ast
Promoter mutations that increa ...... ciated with Alzheimer disease.
@en
Promoter mutations that increa ...... ciated with Alzheimer disease.
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Promoter mutations that increa ...... ciated with Alzheimer disease.
@ast
Promoter mutations that increa ...... ciated with Alzheimer disease.
@en
Promoter mutations that increa ...... ciated with Alzheimer disease.
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P2093
P2860
P50
P356
P1476
Promoter mutations that increa ...... ciated with Alzheimer disease.
@en
P2093
Ellen Corsmit
Peter P De Deyn
Tim De Pooter
Veerle Bogaerts
P2860
P304
P356
10.1086/504044
P407
P50
P577
2006-04-10T00:00:00Z