B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity. - sprookjes - yvandenbroek - TriplyDB

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

http://www.wikidata.org/entity/Q34748194

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Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response Epigenetic Codes Programing Class Switch Recombination Parasite Infection, Carcinogenesis and Human Malignancy Integrative systems medicine approaches to identify molecular targets in lymphoid malignancies Emerging concepts of epigenetic dysregulation in hematological malignancies AID/APOBEC deaminases and cancer RNA Exosome Regulates AID DNA Mutator Activity in the B Cell Genome The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability AID targeting: old mysteries and new challenges Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes dbSUPER: a database of super-enhancers in mouse and human genome Activation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate Cancer.Diffuse large B-cell lymphoma: can genomics improve treatment options for a curable cancer?Eμ and 3'RR IgH enhancers show hierarchic unilateral dependence in mature B-cells.Enhancers as non-coding RNA transcription units: recent insights and future perspectives.SEA: a super-enhancer archive.Epigenetic targeting of activation-induced cytidine deaminase.Non-coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity.Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells.Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia.Exceptional Antibodies Produced by Successive Immunizations.APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions Clusters of Multiple Mutations: Incidence and Molecular Mechanisms Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination PARP activation promotes nuclear AID accumulation in lymphoma cells Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification Defining chromosomal translocation risks in cancer.Better living with hyper-mutation.Activation-Induced Cytidine Deaminase Links Ovulation-Induced Inflammation and Serous Carcinogenesis Genetic dissection of the α-globin super-enhancer in vivo.UNG protects B cells from AID-induced telomere loss.The cell cycle restricts activation-induced cytidine deaminase activity to early G1.Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome.A Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger's CATalytic Pocket.Enhancer-associated RNAs as therapeutic targets.Mechanisms and clinical applications of chromosomal instability in lymphoid malignancy.Restricted, canonical, stereotyped and convergent immunoglobulin responses.

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B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

http://www.wikidata.org/entity/Q34748194

description

2014 nî lūn-bûn

@nan

2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

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name

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

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B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

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B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

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type

label

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

@ast

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

@en

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

@nl

prefLabel

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

@ast

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

@en

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

@nl

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P356

J.CELL.2014.11.013

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P1476

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

@en

P2093

Bin Song

http://www.w3.org/2001/XMLSchema#string

Christopher Benner

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Cornelis Murre

http://www.w3.org/2001/XMLSchema#string

Davide F Robbiani

http://www.w3.org/2001/XMLSchema#string

Ewy Mathé

http://www.w3.org/2001/XMLSchema#string

Geng Liu

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Genqing Liang

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Jason Qian

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Kyong-Rim Kieffer-Kwon

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Laura Vian

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P2860

AID/APOBEC cytosine deaminase induces genome-wide kataegis

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates

Mutational processes molding the genomes of 21 breast cancers

Comprehensive mapping of long-range interactions reveals folding principles of the human genome

Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

Super-enhancers in the control of cell identity and disease

Signatures of mutational processes in human cancer

Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation

Selective inhibition of tumor oncogenes by disruption of super-enhancers

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1524-1537

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scholarly article

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10.1016/J.CELL.2014.11.013

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7

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159

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Michel C. Nussenzweig

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2014-12-04T00:00:00Z

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269282768

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25483777

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4272762

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