about
Biosynthesis and function of polyacetylenes and allied natural productsStructure of Cytochrome P450 PimD Suggests Epoxidation of the Polyene Macrolide Pimaricin Occurs via a Hydroperoxoferric IntermediateMechanistic aspects of CYP74 allene oxide synthases and related cytochrome P450 enzymesA Balancing Act: Stability versus Reactivity of Mn(O) ComplexesCoupling and uncoupling mechanisms in the methoxythreonine mutant of cytochrome P450cam: a quantum mechanical/molecular mechanical study.Probing 'spin-forbidden' oxygen-atom transfer: gas-phase reactions of chromium-porphyrin complexesSynthesis, characterization, and reactivities of manganese(V)-oxo porphyrin complexes.In vitro and in vivo assessment of CYP2C9-mediated herb-herb interaction of Euphorbiae Pekinensis Radix and Glycyrrhizae RadixCytochrome P450(cin) (CYP176A), isolation, expression, and characterization.Elucidating the role of the proximal cysteine hydrogen-bonding network in ferric cytochrome P450cam and corresponding mutants using magnetic circular dichroism spectroscopy.The bioinorganic chemistry of iron in oxygenases and supramolecular assemblies.Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis.Biochemical applications of ultrathin films of enzymes, polyions and DNA.Biological signaling by small inorganic moleculesCompound I is the reactive intermediate in the first monooxygenation step during conversion of cholesterol to pregnenolone by cytochrome P450scc: EPR/ENDOR/cryoreduction/annealing studies.The use of deuterated camphor as a substrate in (1)H ENDOR studies of hydroxylation by cryoreduced oxy P450cam provides new evidence of the involvement of compound IReactivity patterns of cytochrome P450 enzymes: multifunctionality of the active species, and the two states-two oxidants conundrum.Suicide Inhibition of Cytochrome P450 Enzymes by Cyclopropylamines via a Ring-Opening Mechanism: Proton-Coupled Electron Transfer Makes a Difference.Active intermediates in heme monooxygenase reactions as revealed by cryoreduction/annealing, EPR/ENDOR studies.Hydrogen-abstraction reactivity patterns from A to Y: the valence bond way.Diversity of P450 enzymes in the biosynthesis of natural productsOn the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant.Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.To rebound or dissociate? This is the mechanistic question in C-H hydroxylation by heme and nonheme metal-oxo complexes.Oriented electric fields as future smart reagents in chemistry.Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.Biosynthesis of hexahydroxyperylenequinone melanin via oxidative aryl coupling by cytochrome P-450 in Streptomyces griseus.Role of the Proximal Cysteine Hydrogen Bonding Interaction in Cytochrome P450 2B4 Studied by Cryoreduction, Electron Paramagnetic Resonance, and Electron-Nuclear Double Resonance Spectroscopy.Spectroscopic and Kinetic Evidence for the Crucial Role of Compound 0 in the P450cam -Catalyzed Hydroxylation of Camphor by Hydrogen Peroxide.Stabilization and spectroscopic characterization of the dioxygen complex of wild-type cytochrome P4502B4 (CYP2B4) and its distal side E301Q, T302A and proximal side F429H mutants at subzero temperatures.Fractional transfer of a free unpaired electron to overcome energy barriers in the formation of Fe(4+) from Fe(3+) during the core contraction of macrocycles: implication for heme distortion.Molecular design of new inhibitors of peroxidase activity of cytochrome c/cardiolipin complexes: fluorescent oxadiazole-derivatized cardiolipinAnilinic N-oxides support cytochrome P450-mediated N-dealkylation through hydrogen-atom transfer.Characterization of the microsomal cytochrome P450 2B4 O2 activation intermediates by cryoreduction and electron paramagnetic resonance.Direct comparison of the reactivity of model complexes for Compounds 0, I, and II in oxygenation, hydrogen-abstraction, and hydride-transfer processes.Radical rebound mechanism in cytochrome P-450-catalyzed hydroxylation of the multifaceted radical clocks alpha- and beta-thujone.Nitrogen inversion barriers affect the N-oxidation of tertiary alkylamines by cytochromes P450.Iron regulatory protein 2 as iron sensor. Iron-dependent oxidative modification of cysteine.Carbon-carbon bond cleavage by cytochrome p450(BioI)(CYP107H1).Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450BM3-catalysed hydroxylations.
P2860
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P2860
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Oxidizing species in the mechanism of cytochrome P450.
@ast
Oxidizing species in the mechanism of cytochrome P450.
@en
Oxidizing species in the mechanism of cytochrome P450.
@nl
type
label
Oxidizing species in the mechanism of cytochrome P450.
@ast
Oxidizing species in the mechanism of cytochrome P450.
@en
Oxidizing species in the mechanism of cytochrome P450.
@nl
prefLabel
Oxidizing species in the mechanism of cytochrome P450.
@ast
Oxidizing species in the mechanism of cytochrome P450.
@en
Oxidizing species in the mechanism of cytochrome P450.
@nl
P356
P1476
Oxidizing species in the mechanism of cytochrome P450.
@en
P2093
James J De Voss
Paul R Ortiz de Montellano
P304
P356
10.1039/B101297P
P577
2002-08-01T00:00:00Z