Challenges and advances in validating enzyme design proposals: the case of kemp eliminase catalysis
about
Computer aided enzyme design and catalytic conceptsEngineering a model protein cavity to catalyze the Kemp eliminationPerspective: Defining and quantifying the role of dynamics in enzyme catalysisComputational protein engineering: bridging the gap between rational design and laboratory evolution.Examining the promiscuous phosphatase activity of Pseudomonas aeruginosa arylsulfatase: a comparison to analogous phosphatases.Computer-Aided Protein Directed Evolution: a Review of Web Servers, Databases and other Computational Tools for Protein EngineeringValidating the vitality strategy for fighting drug resistance.Expanding the Catalytic Triad in Epoxide Hydrolases and Related Enzymes.Computational strategies for the design of new enzymatic functionsCADEE: Computer-Aided Directed Evolution of Enzymes.Structure Activity Related, Mechanistic, and Modeling Studies of Gallotannins containing a Glucitol-Core and α-GlucosidaseEmerging themes in the computational design of novel enzymes and protein-protein interfaces.Why nature really chose phosphate.Computational enzyme design.Computational Enzyme Design: Advances, hurdles and possible ways forwardRecent advances in rational approaches for enzyme engineering.Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.A redox-mediated Kemp eliminase.The role of side chain entropy and mutual information for improving the de novo design of Kemp eliminases KE07 and KE70.Elucidating the 3D structures of Al(iii)-Aβ complexes: a template free strategy based on the pre-organization hypothesis.Simulating the catalytic effect of a designed mononuclear zinc metalloenzyme that catalyzes the hydrolysis of phosphate triesters.Computational design of a Diels-Alderase from a thermophilic esterase: the importance of dynamics.Exploring the Development of Ground-State Destabilization and Transition-State Stabilization in Two Directed Evolution Paths of Kemp Eliminases.Revealing the Origin of the Efficiency of the De Novo Designed Kemp Eliminase HG-3.17 by Comparison with the Former Developed HG-3.Prechemistry barriers and checkpoints do not contribute to fidelity and catalysis as long as they are not rate limitingThe evolution of multiple active site configurations in a designed enzyme
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P2860
Challenges and advances in validating enzyme design proposals: the case of kemp eliminase catalysis
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2011 nî lūn-bûn
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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2011 թվականի ապրիլին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
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2011年论文
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name
Challenges and advances in val ...... se of kemp eliminase catalysis
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Challenges and advances in val ...... se of kemp eliminase catalysis
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Challenges and advances in val ...... se of kemp eliminase catalysis
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Challenges and advances in val ...... se of kemp eliminase catalysis
@ast
Challenges and advances in val ...... se of kemp eliminase catalysis
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Challenges and advances in val ...... se of kemp eliminase catalysis
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prefLabel
Challenges and advances in val ...... se of kemp eliminase catalysis
@ast
Challenges and advances in val ...... se of kemp eliminase catalysis
@en
Challenges and advances in val ...... se of kemp eliminase catalysis
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P2860
P356
P1433
P1476
Challenges and advances in val ...... se of kemp eliminase catalysis
@en
P2093
Maria P Frushicheva
P2860
P304
P356
10.1021/BI200063A
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P577
2011-04-15T00:00:00Z