INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties.
about
Synthesis of nucleoside phosphate and phosphonate prodrugsChutes and ladders in hepatitis C nucleoside drug developmentProdrugs of phosphonates and phosphates: crossing the membrane barrierBroad-spectrum agents for flaviviral infections: dengue, Zika and beyondBarriers of hepatitis C virus interspecies transmissionInvestigational nucleoside and nucleotide polymerase inhibitors and their use in treating hepatitis C virus.Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs.Highlights in antiviral drug research: antivirals at the horizon.Current and future therapies for hepatitis C virus infection: from viral proteins to host targets.Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus.Targeting translation: eIF4E as an emerging anticancer drug target.Synergistic suppression of dengue virus replication using a combination of nucleoside analogs and nucleoside synthesis inhibitors.Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor.Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA.Discontinued drugs in 2012 - 2013: hepatitis C virus infection.Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.The ProTides Boom.Molecular modeling study on the drug resistance mechanism of NS5B polymerase to TMC647055.Pharmacokinetics of IDX184, a liver-targeted oral prodrug of 2'-methylguanosine-5'-monophosphate, in the monkey and formulation optimization for human exposure.Cardiac dysfunction associated with a nucleotide polymerase inhibitor for treatment of hepatitis C.Synthesis of phosphoramidate prodrugs: ProTide approach.
P2860
Q26865400-1F43E4E6-77F2-4522-9552-885C56373F82Q26998630-E58285FA-F1ED-42AC-B97E-C5D281D737C4Q27005712-6D7DA48E-0B01-4A23-AEAA-D2A30C402F6FQ29994527-D59BBF8D-E0ED-4BFB-B09A-D090B5790D10Q34315915-B38D25ED-A6B2-4BBC-B4AC-944D0C720C91Q34420891-ABA99A7B-4278-45B5-953D-B36E8401D462Q37998132-A9B081DB-1FDD-49F2-A539-B91B1F6B3718Q38007145-DCE32BEE-A69D-4002-8754-07277FE4F6D6Q38131681-F2DC45DA-85C4-4E31-90DF-3FEFE9D8AC49Q38367690-011A7518-1B55-479C-8113-5937912C6647Q38699320-8D2848D7-C5A3-4522-8731-E01196C29CEAQ38916167-8E72D214-8CA1-458B-958E-865884D1F753Q38958064-75E7CBE2-C860-43E4-8C03-1F60992F9B5EQ38961245-D9E08869-5928-42B2-9824-996252B27142Q39100351-AEC8EEBF-B230-4FF0-9256-493D8FD70870Q39376758-3DE10A91-DFA2-403E-9FF3-817EEB253ABAQ39742470-72327103-2DE9-4437-BE2C-4989992BD347Q40682239-88E37E27-5DD6-4FD4-90D1-FA45BD03E424Q40935601-0C0C5787-08A1-424C-912B-F7F112DEF566Q41033851-08C7BA61-4070-41F1-A966-A4B7F47B85DFQ41728099-EE3F3642-FA7F-4C5C-8348-32986AED6EEEQ42993295-8BB431DC-5BF7-4EE2-83B6-ED4AAE0865F9
P2860
INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties.
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
INX-08189, a phosphoramidate p ...... nd pharmacodynamic properties.
@ast
INX-08189, a phosphoramidate p ...... nd pharmacodynamic properties.
@en
INX-08189, a phosphoramidate p ...... nd pharmacodynamic properties.
@nl
type
label
INX-08189, a phosphoramidate p ...... nd pharmacodynamic properties.
@ast
INX-08189, a phosphoramidate p ...... nd pharmacodynamic properties.
@en
INX-08189, a phosphoramidate p ...... nd pharmacodynamic properties.
@nl
prefLabel
INX-08189, a phosphoramidate p ...... nd pharmacodynamic properties.
@ast
INX-08189, a phosphoramidate p ...... nd pharmacodynamic properties.
@en
INX-08189, a phosphoramidate p ...... nd pharmacodynamic properties.
@nl
P2093
P2860
P356
P1476
INX-08189, a phosphoramidate p ...... and pharmacodynamic properties
@en
P2093
Alexander Kolykhalov
Andrea Hall
Babita Ganguly
Blair Bleiman
Brenda Ames
C Robin Walters
Damound Hunley
Elena Gorovits
Geoffrey Henson
Jeff Hutchins
P2860
P304
P356
10.1128/AAC.01335-10
P407
P577
2011-02-28T00:00:00Z