mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation. - sprookjes - yvandenbroek - TriplyDB

mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.

mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.

http://www.wikidata.org/entity/Q34965452

about

Targeting LKB1 in cancer - exposing and exploiting vulnerabilities Genetics of melanocytic nevi Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression.Expression of oncogenic BRAFV600E in melanocytes induces Schwannian differentiation in vivo.CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma.PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma.AKT1 Activation Promotes Development of Melanoma Metastases.Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression Oncogenic BRAF-Mediated Melanoma Cell Invasion.Melanoma metastases caught in the AKT Immunogenic, cellular, and angiogenic drivers of tumor dormancy--a melanoma view.Melanocytic nevi and melanoma: unraveling a complex relationship.DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR.Evaluation of tubulin β-3 as a novel senescence-associated gene in melanocytic malignant transformation.Genetically engineered mouse models of melanoma.Intratumoral delivery of mTORC2-deficient dendritic cells inhibits B16 melanoma growth by promoting CD8(+) effector T cell responses.The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer.Induction of Therapeutic Senescence in Vemurafenib-Resistant Melanoma by Extended Inhibition of CDK4/6 The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168.LKB1 loss cooperating with BRAF V600E promotes melanoma cell invasion and migration by up-regulation MMP-2 via PI3K/Akt/mTOR pathway.Attenuation of genome-wide 5-methylcytosine level is an epigenetic feature of cutaneous malignant melanomas.Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation.mTOR signaling-related MicroRNAs and Cancer involvement.CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought Acquired resistance to BRAFi reverses senescence-like phenotype in mutant BRAF melanoma

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mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.

http://www.wikidata.org/entity/Q34965452

description

2015 nî lūn-bûn

@nan

2015 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2015 թվականի հունվարին հրատարակված գիտական հոդված

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年學術文章

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name

mTORC1 activation blocks BrafV ...... icient for melanoma formation.

@ast

mTORC1 activation blocks BrafV ...... icient for melanoma formation.

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mTORC1 activation blocks BrafV ...... icient for melanoma formation.

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type

label

mTORC1 activation blocks BrafV ...... icient for melanoma formation.

@ast

mTORC1 activation blocks BrafV ...... icient for melanoma formation.

@en

mTORC1 activation blocks BrafV ...... icient for melanoma formation.

@nl

prefLabel

mTORC1 activation blocks BrafV ...... icient for melanoma formation.

@ast

mTORC1 activation blocks BrafV ...... icient for melanoma formation.

@en

mTORC1 activation blocks BrafV ...... icient for melanoma formation.

@nl

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J.CCELL.2014.11.014

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mTORC1 activation blocks BrafV ...... icient for melanoma formation.

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David P Curley

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Glenn Merlino

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Ildiko Erdelyi

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James T Platt

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Katrina Meeth

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Laura Huang

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Manjula Santhanakrishnan

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Marcus Bosenberg

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Martin McMahon

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Michael A Davies

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P2860

Autophagy mediates the mitotic senescence transition

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

Interferon-γ links ultraviolet radiation to melanomagenesis in mice

The Catalogue of Somatic Mutations in Cancer (COSMIC)

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

Melanoma: from mutations to medicine

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF

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