The promise and potential pitfalls of chimeric antigen receptors.
about
Focus on adoptive T cell transfer trials in melanomaChimeric antigen receptor-modified T cells in chronic lymphoid leukemiaT cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemiaSynthetic conversion of a graded receptor signal into a tunable, reversible switchProducer T cells: Using genetically engineered T cells as vehicles to generate and deliver therapeutics to tumorsChimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and ProspectsAdoptive immunotherapy for acute leukemia: New insights in chimeric antigen receptorsGenetic instability in the tumor microenvironment: a new look at an old neighborCARs in chronic lymphocytic leukemia -- ready to driveA new approach to gene therapy using Sleeping Beauty to genetically modify clinical-grade T cells to target CD19Developing strategies in the immunotherapy of leukemiasPrimer on tumor immunology and cancer immunotherapyNovel immunotherapies for hematologic malignanciesClinical application of adoptive T cell therapy in solid tumorsImmunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapiesNovel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive reviewOne-step enzymatic modification of the cell surface redirects cellular cytotoxicity and parasite tropism.Identification of Amino Acids that Account for Long-Range Interactions in Two Triosephosphate Isomerases from Pathogenic TrypanosomesCAR therapy: the CD19 paradigmB-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cellsSafety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemiasPD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responsesT cell receptor (TCR) gene therapy to treat melanoma: lessons from clinical and preclinical studies.Immune-based therapeutics for pediatric cancer.FCγ Chimeric Receptor-Engineered T Cells: Methodology, Advantages, Limitations, and Clinical RelevanceStrategies to genetically engineer T cells for cancer immunotherapy.Immunotherapy of childhood cancer: from biologic understanding to clinical application.Biology and clinical application of CAR T cells for B cell malignanciesMathematical modeling of chimeric TCR triggering predicts the magnitude of target lysis and its impairment by TCR downmodulationSuccessful eradication of established peritoneal ovarian tumors in SCID-Beige mice following adoptive transfer of T cells genetically targeted to the MUC16 antigen.The basic principles of chimeric antigen receptor design.Retargeting NK92 cells using an HLA-A2-restricted, EBNA3C-specific chimeric antigen receptor.Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits.Alloantigen-specific regulatory T cells generated with a chimeric antigen receptorSelective expansion of chimeric antigen receptor-targeted T-cells with potent effector function using interleukin-4.Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor.Armed and accurate: engineering cytotoxic T cells for eradication of leukemia.Redirecting T cells to Ewing's sarcoma family of tumors by a chimeric NKG2D receptor expressed by lentiviral transduction or mRNA transfection.Immunotherapy of human cancers using gene modified T lymphocytes.Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells.
P2860
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P2860
The promise and potential pitfalls of chimeric antigen receptors.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
The promise and potential pitfalls of chimeric antigen receptors.
@ast
The promise and potential pitfalls of chimeric antigen receptors.
@en
The promise and potential pitfalls of chimeric antigen receptors.
@nl
type
label
The promise and potential pitfalls of chimeric antigen receptors.
@ast
The promise and potential pitfalls of chimeric antigen receptors.
@en
The promise and potential pitfalls of chimeric antigen receptors.
@nl
prefLabel
The promise and potential pitfalls of chimeric antigen receptors.
@ast
The promise and potential pitfalls of chimeric antigen receptors.
@en
The promise and potential pitfalls of chimeric antigen receptors.
@nl
P2093
P2860
P1476
The promise and potential pitfalls of chimeric antigen receptors.
@en
P2093
Isabelle Rivière
Michel Sadelain
Renier Brentjens
P2860
P304
P356
10.1016/J.COI.2009.02.009
P577
2009-03-25T00:00:00Z