Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I
about
Dynamic Ca2+-dependent stimulation of vesicle fusion by membrane-anchored synaptotagmin 1Regulation of intracellular membrane trafficking and cell dynamics by syntaxin-6Lateral diffusion of proteins on supported lipid bilayers: additive friction of synaptotagmin 7 C2A-C2B tandem domains.Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain associationMolecular mechanism of the synaptotagmin–SNARE interaction in Ca2+-triggered vesicle fusionCis- and trans-membrane interactions of synaptotagmin-1Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoformsRing-like oligomers of Synaptotagmins and related C2 domain proteinsThe juxtamembrane linker of full-length synaptotagmin 1 controls oligomerization and calcium-dependent membrane binding.The N-terminal domain tethers the voltage-gated calcium channel β2e-subunit to the plasma membrane via electrostatic and hydrophobic interactionsSolution and membrane-bound conformations of the tandem C2A and C2B domains of synaptotagmin 1: Evidence for bilayer bridgingThe calcium-dependent and calcium-independent membrane binding of synaptotagmin 1: two modes of C2B binding.Cross-linking of phospholipid membranes is a conserved property of calcium-sensitive synaptotagminsInteraction of synaptotagmin with lipid bilayers, analyzed by single-molecule force spectroscopy.Myoblast fusion: when it takes more to make one.Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity.Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission.Characterization of the lipid binding properties of Otoferlin reveals specific interactions between PI(4,5)P2 and the C2C and C2F domains.Synaptotagmin's role in neurotransmitter release likely involves Ca(2+)-induced conformational transition.The Arabidopsis synaptotagmin SYTA regulates the cell-to-cell movement of diverse plant virusesRubella virus: first calcium-requiring viral fusion protein.New insights into short-term synaptic facilitation at the frog neuromuscular junction.Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation.Mechanism and function of synaptotagmin-mediated membrane apposition.Calcium binding promotes conformational flexibility of the neuronal Ca(2+) sensor synaptotagmin.Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release.Dysferlin and muscle membrane repair.Different states of synaptotagmin regulate evoked versus spontaneous release.Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+.Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release.A time course of orchestrated endophilin action in sensing, bending, and stabilizing curved membranes.Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin.Mutations that disrupt Ca²⁺-binding activity endow Doc2β with novel functional properties during synaptic transmission.Control of membrane gaps by synaptotagmin-Ca2+ measured with a novel membrane distance rulerHydrophobic contributions to the membrane docking of synaptotagmin 7 C2A domain: mechanistic contrast between isoforms 1 and 7Circular oligomerization is an intrinsic property of synaptotagmin.C2-domain containing calcium sensors in neuroendocrine secretion.Effect of PIP2 binding on the membrane docking geometry of PKC alpha C2 domain: an EPR site-directed spin-labeling and relaxation studyThe endocytic recycling protein EHD2 interacts with myoferlin to regulate myoblast fusion.Distinct roles of the C2A and the C2B domain of the vesicular Ca2+ sensor synaptotagmin 9 in endocrine beta-cells.
P2860
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P2860
Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
name
Ca2+-triggered simultaneous me ...... C2-domains of synaptotagmin I
@ast
Ca2+-triggered simultaneous me ...... C2-domains of synaptotagmin I
@en
Ca2+-triggered simultaneous me ...... C2-domains of synaptotagmin I
@nl
type
label
Ca2+-triggered simultaneous me ...... C2-domains of synaptotagmin I
@ast
Ca2+-triggered simultaneous me ...... C2-domains of synaptotagmin I
@en
Ca2+-triggered simultaneous me ...... C2-domains of synaptotagmin I
@nl
prefLabel
Ca2+-triggered simultaneous me ...... C2-domains of synaptotagmin I
@ast
Ca2+-triggered simultaneous me ...... C2-domains of synaptotagmin I
@en
Ca2+-triggered simultaneous me ...... C2-domains of synaptotagmin I
@nl
P2093
P2860
P1433
P1476
Ca2+-triggered simultaneous me ...... C2-domains of synaptotagmin I
@en
P2093
Edwin R Chapman
Jihong Bai
P2860
P304
P356
10.1529/BIOPHYSJ.105.080325
P407
P577
2006-06-16T00:00:00Z